CD120 ( Cluster of Differentiation 120), also known as the tumor necrosis factor receptor (TNFR). This protein is a member of the tumor necrosis factor receptor superfamily. [1 ] [2 ]
Receptor subtypes [ edit ]
There are two variants of the receptor, each encoded by a separate gene:
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,
and is involved in neurotoxic processes. [3 ] Elevated levels of TNFR1 has been found in severe mental disorders. [4 ] [5 ]
Signaling pathway [ edit ]
Signaling pathway of
-R1. Dashed grey lines represent multiple steps
See also [ edit ]
References [ edit ]
^ Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi: 10.1016/S0092-8674(01)00237-9. PMID 11239407.
^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi: 10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693.
^ Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009). "The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior". Psychopharmacology (Berl.) 201 (4): 549–56. doi: 10.1007/s00213-008-1331-4. PMC 2711641. PMID 18825372.
^ McCoy MK, Tansey MG (2008). "TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease". J Neuroinflammation 5 (1): 45. doi: 10.1186/1742-2094-5-45. PMC 2577641. PMID 18925972.
^ Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord 11 (7): 726–34. doi: 10.1111/j.1399-5618.2009.00757.x. PMID 19839997.
External links [ edit ]