CD226

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CD226 molecule
Identifiers
Symbols CD226 ; DNAM-1; DNAM1; PTA1; TLiSA1
External IDs OMIM605397 MGI3039602 HomoloGene4787 GeneCards: CD226 Gene
RNA expression pattern
PBB GE CD226 207315 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10666 225825
Ensembl ENSG00000150637 ENSMUSG00000034028
UniProt Q15762 Q8K4F0
RefSeq (mRNA) NM_006566 NM_001039148
RefSeq (protein) NP_006557 NP_001034238
Location (UCSC) Chr 18:
67.5 – 67.63 Mb
Chr 18:
89.2 – 89.27 Mb
PubMed search [1] [2]

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')[1] or DNAM-1 (DNAX Accessory Molecule-1)[1] is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.[2]

Structure and function[edit]

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,[3][4] and cross-linking CD226 with antibodies causes cellular activation.[2]

See also[edit]

References[edit]

  1. ^ a b Fuchs, Anja; Colonna, M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340. 
  2. ^ a b "Entrez Gene: CD226 CD226 molecule". 
  3. ^ Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". J. Exp. Med. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096. 
  4. ^ Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". Int. Immunol. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.