Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCRgene. PROCR has also recently been designated CD201 (cluster of differentiation 201).
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C.
^Fukudome K, Esmon CT (Nov 1994). "Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor". J Biol Chem269 (42): 26486–91. PMID7929370.
^Rothbarth K, Dabaghian AR, Stammer H, Werner D (Oct 1999). "One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR)". FEBS Lett458 (1): 77–80. doi:10.1016/S0014-5793(99)01074-1. PMID10518938.
Laszik Z, Mitro A, Taylor FB, et al. (1998). "Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway.". Circulation96 (10): 3633–40. doi:10.1161/01.cir.96.10.3633. PMID9396465.
Ye X, Fukudome K, Tsuneyoshi N, et al. (1999). "The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries.". Biochem. Biophys. Res. Commun.259 (3): 671–7. doi:10.1006/bbrc.1999.0846. PMID10364477.
Simmonds RE, Lane DA (1999). "Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains.". Blood94 (2): 632–41. PMID10397730.
Liaw PC, Neuenschwander PF, Smirnov MD, Esmon CT (2000). "Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function.". J. Biol. Chem.275 (8): 5447–52. doi:10.1074/jbc.275.8.5447. PMID10681521.
Liaw PC, Mather T, Oganesyan N, et al. (2001). "Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor.". J. Biol. Chem.276 (11): 8364–70. doi:10.1074/jbc.M010572200. PMID11099506.
Biguzzi E, Merati G, Liaw PC, et al. (2002). "A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function.". Thromb. Haemost.86 (4): 945–8. PMID11686350.
von Depka M, Czwalinna A, Eisert R, et al. (2002). "Prevalence of a 23bp insertion in exon 3 of the endothelial cell protein C receptor gene in venous thrombophilia.". Thromb. Haemost.86 (6): 1360–2. PMID11776299.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature414 (6866): 865–71. doi:10.1038/414865a. PMID11780052.
Oganesyan V, Oganesyan N, Terzyan S, et al. (2002). "The crystal structure of the endothelial protein C receptor and a bound phospholipid.". J. Biol. Chem.277 (28): 24851–4. doi:10.1074/jbc.C200163200. PMID12034704.
Riewald M, Petrovan RJ, Donner A, et al. (2002). "Activation of endothelial cell protease activated receptor 1 by the protein C pathway.". Science296 (5574): 1880–2. doi:10.1126/science.1071699. PMID12052963.