Endothelial protein C receptor

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"EPCR" redirects here. For the European rugby governing body, see European Professional Club Rugby.
Protein C receptor, endothelial
Protein PROCR PDB 1l8j.png
PDB rendering based on 1l8j.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PROCR ; CCCA; CCD41; CD201; EPCR
External IDs OMIM600646 MGI104596 HomoloGene4670 ChEMBL: 5392 GeneCards: PROCR Gene
RNA expression pattern
PBB GE PROCR 203650 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10544 19124
Ensembl ENSG00000101000 ENSMUSG00000027611
UniProt Q9UNN8 Q64695
RefSeq (mRNA) NM_006404 NM_011171
RefSeq (protein) NP_006395 NP_035301
Location (UCSC) Chr 20:
33.76 – 33.77 Mb
Chr 2:
155.75 – 155.76 Mb
PubMed search [1] [2]

Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene.[1][2][3] PROCR has also recently been designated CD201 (cluster of differentiation 201).

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C.[3]

Clinical significance[edit]

Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.[3]

The protein is also involved in Plasmodium falciparum malaria as subtypes of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family use EPCR of the host as a receptor.[4]

References[edit]

  1. ^ Fukudome K, Esmon CT (Nov 1994). "Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor". J Biol Chem 269 (42): 26486–91. PMID 7929370. 
  2. ^ Rothbarth K, Dabaghian AR, Stammer H, Werner D (Oct 1999). "One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR)". FEBS Lett 458 (1): 77–80. doi:10.1016/S0014-5793(99)01074-1. PMID 10518938. 
  3. ^ a b c "Entrez Gene: PROCR protein C receptor, endothelial (EPCR)". 
  4. ^ Louise Turner and others (2013). Severe malaria is associated with parasite binding to endothelial protein C receptor. Nature. doi:10.1038/nature12216. 

Further reading[edit]

  • Esmon CT (2004). "Coagulation and inflammation.". J. Endotoxin Res. 9 (3): 192–8. doi:10.1179/096805103125001603. PMID 12831462. 
  • Ruf W, Dorfleutner A, Riewald M (2003). "Specificity of coagulation factor signaling.". J. Thromb. Haemost. 1 (7): 1495–503. doi:10.1046/j.1538-7836.2003.00300.x. PMID 12871285. 
  • Van de Wouwer M, Collen D, Conway EM (2005). "Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1374–83. doi:10.1161/01.ATV.0000134298.25489.92. PMID 15178554. 
  • Medina P, Navarro S, Estellés A, España F (2007). "Polymorphisms in the endothelial protein C receptor gene and thrombophilia.". Thromb. Haemost. 98 (3): 564–9. doi:10.1160/th07-01-0071. PMID 17849044. 
  • Raheja KK (1977). "Nursing in transition.". Nursing forum 15 (4): 413–7. doi:10.1111/j.1744-6198.1976.tb01065.x. PMID 1051893. 
  • Laszik Z, Mitro A, Taylor FB, et al. (1998). "Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway.". Circulation 96 (10): 3633–40. doi:10.1161/01.cir.96.10.3633. PMID 9396465. 
  • Ye X, Fukudome K, Tsuneyoshi N, et al. (1999). "The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries.". Biochem. Biophys. Res. Commun. 259 (3): 671–7. doi:10.1006/bbrc.1999.0846. PMID 10364477. 
  • Simmonds RE, Lane DA (1999). "Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains.". Blood 94 (2): 632–41. PMID 10397730. 
  • Hayashi T, Nakamura H, Okada A, et al. (1999). "Organization and chromosomal localization of the human endothelial protein C receptor gene.". Gene 238 (2): 367–73. doi:10.1016/S0378-1119(99)00360-1. PMID 10570964. 
  • Liaw PC, Neuenschwander PF, Smirnov MD, Esmon CT (2000). "Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function.". J. Biol. Chem. 275 (8): 5447–52. doi:10.1074/jbc.275.8.5447. PMID 10681521. 
  • Xu J, Qu D, Esmon NL, Esmon CT (2000). "Metalloproteolytic release of endothelial cell protein C receptor.". J. Biol. Chem. 275 (8): 6038–44. doi:10.1074/jbc.275.8.6038. PMID 10681599. 
  • Liaw PC, Mather T, Oganesyan N, et al. (2001). "Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor.". J. Biol. Chem. 276 (11): 8364–70. doi:10.1074/jbc.M010572200. PMID 11099506. 
  • Biguzzi E, Merati G, Liaw PC, et al. (2002). "A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function.". Thromb. Haemost. 86 (4): 945–8. PMID 11686350. 
  • Galligan L, Livingstone W, Volkov Y, et al. (2001). "Characterization of protein C receptor expression in monocytes.". Br. J. Haematol. 115 (2): 408–14. doi:10.1046/j.1365-2141.2001.03187.x. PMID 11703343. 
  • von Depka M, Czwalinna A, Eisert R, et al. (2002). "Prevalence of a 23bp insertion in exon 3 of the endothelial cell protein C receptor gene in venous thrombophilia.". Thromb. Haemost. 86 (6): 1360–2. PMID 11776299. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Oganesyan V, Oganesyan N, Terzyan S, et al. (2002). "The crystal structure of the endothelial protein C receptor and a bound phospholipid.". J. Biol. Chem. 277 (28): 24851–4. doi:10.1074/jbc.C200163200. PMID 12034704. 
  • Riewald M, Petrovan RJ, Donner A, et al. (2002). "Activation of endothelial cell protease activated receptor 1 by the protein C pathway.". Science 296 (5574): 1880–2. doi:10.1126/science.1071699. PMID 12052963. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.