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Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Protein SEMA4D PDB 1olz.png
PDB rendering based on 1olz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SEMA4D ; C9orf164; CD100; M-sema-G; SEMAJ; coll-4
External IDs OMIM601866 MGI109244 HomoloGene21282 GeneCards: SEMA4D Gene
RNA expression pattern
PBB GE SEMA4D 203528 at tn.png
More reference expression data
Species Human Mouse
Entrez 10507 20354
Ensembl ENSG00000187764 ENSMUSG00000021451
UniProt Q92854 O09126
RefSeq (mRNA) NM_001142287 NM_001281880
RefSeq (protein) NP_001135759 NP_001268809
Location (UCSC) Chr 9:
91.98 – 92.11 Mb
Chr 13:
51.7 – 51.79 Mb
PubMed search [1] [2]

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.[1]


Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.[2]

In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation.[3][4]

During skin damage repairs, SEMA4D interacts with Plexin B2 on gamma delta t cells to play a role in the healing process.[5]

See also[edit]


  1. ^ "Entrez Gene: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D". 
  2. ^ Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (July 2006). "Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse". EMBO Reports 7 (7): 704–9. doi:10.1038/sj.embor.7400737. PMC 1500830. PMID 16799460. 
  3. ^ Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H (November 2000). "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling". Immunity 13 (5): 621–31. doi:10.1016/S1074-7613(00)00062-5. PMID 11114375. 
  4. ^ Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H (August 2003). "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses". Int. Immunol. 15 (8): 1027–34. doi:10.1093/intimm/dxg098. PMID 12882840. 
  5. ^ Deborah A. Witherden, Megumi Watanabe, Olivia Garijo, Stephanie E. Rieder, Gor Sarkisyan, Shane J.F. Cronin, Petra Verdino, Ian A. Wilson, Atsushi Kumanogoh, Hitoshi Kikutani, Luc Teyton, Wolfgang H. Fischer, Wendy L. Havran (August 2012). "The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function". Immunity 37 (2): 314–25. doi:10.1016/j.immuni.2012.05.026. 

Further reading[edit]

External links[edit]