CD8A

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CD8a molecule

PDB rendering based on 1akj.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CD8A ; CD8; Leu2; MAL; p32
External IDs OMIM186910 MGI88346 HomoloGene1339 GeneCards: CD8A Gene
RNA expression pattern
PBB GE CD8A 205758 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 925 12525
Ensembl ENSG00000153563 ENSMUSG00000053977
UniProt P01732 P01731
RefSeq (mRNA) NM_001145873 NM_001081110
RefSeq (protein) NP_001139345 NP_001074579
Location (UCSC) Chr 2:
87.01 – 87.04 Mb
Chr 6:
71.37 – 71.38 Mb
PubMed search [1] [2]

CD8a (Cluster of Differentiation 8a), is a human gene.[1]

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.[1]

Interactions[edit]

CD8A has been shown to interact with CD3D,[2] HLA-G[3][4] and HLA-A.[3][5]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: CD8A CD8a molecule". 
  2. ^ Doucey, Marie-Agnès; Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (January 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. (United States) 278 (5): 3257–64. doi:10.1074/jbc.M208119200. ISSN 0021-9258. PMID 12215456. 
  3. ^ a b Gao, G F; Willcox B E, Wyer J R, Boulter J M, O'Callaghan C A, Maenaka K, Stuart D I, Jones E Y, Van Der Merwe P A, Bell J I, Jakobsen B K (May 2000). "Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha". J. Biol. Chem. (UNITED STATES) 275 (20): 15232–8. doi:10.1074/jbc.275.20.15232. ISSN 0021-9258. PMID 10809759. 
  4. ^ Sanders, S K; Giblin P A, Kavathas P (September 1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. (UNITED STATES) 174 (3): 737–40. doi:10.1084/jem.174.3.737. ISSN 0022-1007. PMC 2118947. PMID 1908512. 
  5. ^ Gao, G F; Tormo J, Gerth U C, Wyer J R, McMichael A J, Stuart D I, Bell J I, Jones E Y, Jakobsen B K (June 1997). "Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2". Nature (ENGLAND) 387 (6633): 630–4. doi:10.1038/42523. ISSN 0028-0836. PMID 9177355. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.