The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.
^Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature386 (6621): 181–6. doi:10.1038/386181a0. PMID9062191.
^van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol175 (12): 7788–9. PMID16339511.
^Dietrich, J; Cella M, Seiffert M, Bühring H J, Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. (UNITED STATES) 164 (1): 9–12. ISSN0022-1767. PMID10604985.Cite uses deprecated parameters (help)
Dietrich J, Cella M, Seiffert M, et al. (2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.". J. Immunol.164 (1): 9–12. PMID10604985.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature414 (6866): 865–71. doi:10.1038/414865a. PMID11780052.
Cannon JP, Haire RN, Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate.". Nat. Immunol.3 (12): 1200–7. doi:10.1038/ni849. PMID12415263.
Liu Y, Soto I, Tong Q, et al. (2006). "SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration". J. Biol. Chem.280 (43): 36132–40. doi:10.1074/jbc.M506419200. PMID16081415.