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CD109 molecule
Symbols CD109 ; CPAMD7; p180; r150
External IDs OMIM608859 MGI2445221 HomoloGene25183 GeneCards: CD109 Gene
RNA expression pattern
PBB GE CD109 gnf1h04600 at tn.png
PBB GE CD109 gnf1h06370 at tn.png
PBB GE CD109 gnf1h07791 at tn.png
More reference expression data
Species Human Mouse
Entrez 135228 235505
Ensembl ENSG00000156535 ENSMUSG00000046186
UniProt Q6YHK3 Q8R422
RefSeq (mRNA) NM_001159587 NM_153098
RefSeq (protein) NP_001153059 NP_694738
Location (UCSC) Chr 6:
74.41 – 74.54 Mb
Chr 9:
78.62 – 78.72 Mb
PubMed search [1] [2]

CD109 (Cluster of Differentiation 109) is a human gene.[1]

CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system, implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM][1]

See also[edit]


Further reading[edit]

  • Lucas GF, Metcalfe P (2000). "Platelet and granulocyte glycoprotein polymorphisms.". Transfusion medicine (Oxford, England) 10 (3): 157–74. doi:10.1046/j.1365-3148.2000.00250.x. PMID 10972910. 
  • Sutherland DR, Yeo E, Ryan A et al. (1991). "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets.". Blood 77 (1): 84–93. PMID 1984805. 
  • Kelton JG, Smith JW, Horsewood P et al. (1990). "Gova/b alloantigen system on human platelets.". Blood 75 (11): 2172–6. PMID 2346781. 
  • Lin M, Sutherland DR, Horsfall W et al. (2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins.". Blood 99 (5): 1683–91. doi:10.1182/blood.V99.5.1683. PMID 11861284. 
  • Schuh AC, Watkins NA, Nguyen Q et al. (2002). "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.". Blood 99 (5): 1692–8. doi:10.1182/blood.V99.5.1692. PMID 11861285. 
  • Giesert C, Marxer A, Sutherland DR et al. (2003). "Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets.". Ann. N. Y. Acad. Sci. 996: 227–30. doi:10.1111/j.1749-6632.2003.tb03250.x. PMID 12799300. 
  • Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Solomon KR, Sharma P, Chan M et al. (2004). "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family.". Gene 327 (2): 171–83. doi:10.1016/j.gene.2003.11.025. PMID 14980714. 
  • Zhang JM, Hashimoto M, Kawai K et al. (2005). "CD109 expression in squamous cell carcinoma of the uterine cervix.". Pathol. Int. 55 (4): 165–9. doi:10.1111/j.1440-1827.2005.01807.x. PMID 15826242. 
  • Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.". Mol. Cell Proteomics 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699. 
  • Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. 
  • Finnson KW, Tam BY, Liu K et al. (2006). "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes". FASEB J. 20 (9): 1525–7. doi:10.1096/fj.05-5229fje. PMID 16754747. 
  • Sjöblom T, Jones S, Wood LD et al. (2006). "The consensus coding sequences of human breast and colorectal cancers". Science 314 (5797): 268–74. doi:10.1126/science.1133427. PMID 16959974. 
  • Hasegawa M, Hagiwara S, Sato T et al. (2007). "CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells". Pathol. Int. 57 (5): 245–50. doi:10.1111/j.1440-1827.2007.02097.x. PMID 17493171. 

External links[edit]