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{{Infobox_gene}}
{{Infobox_gene}}
'''Intercellular adhesion molecule 3''' ('''ICAM3''') also known as '''CD50''' ('''C'''luster of '''D'''ifferentiation '''50'''), is a [[protein]] that in humans is encoded by the ''ICAM3'' [[gene]].<ref>{{Cite web |title=ICAM3 intercellular adhesion molecule 3 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/3385 |access-date=2022-03-10 |website=www.ncbi.nlm.nih.gov}}</ref> The protein is constitutively expressed on the surface of [[White blood cell|leukocytes]], which are also called white blood cells and are part of the immune system.<ref>{{Cite journal |last=Xiao |first=Xiang |last2=Mruk |first2=Dolores D. |last3=Cheng |first3=C. Yan |date=2013-3 |title=Intercellular adhesion molecules (ICAMs) and spermatogenesis |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576004/ |journal=Human Reproduction Update |volume=19 |issue=2 |pages=167–186 |doi=10.1093/humupd/dms049 |issn=1355-4786 |pmc=3576004 |pmid=23287428}}</ref><ref>{{Cite journal |last=Pastwińska |first=Joanna |last2=Żelechowska |first2=Paulina |last3=Walczak-Drzewiecka |first3=Aurelia |last4=Brzezińska-Błaszczyk |first4=Ewa |last5=Dastych |first5=Jarosław |date=2020-12 |title=The Art of Mast Cell Adhesion |url=https://www.mdpi.com/2073-4409/9/12/2664 |journal=Cells |language=en |volume=9 |issue=12 |pages=2664 |doi=10.3390/cells9122664 |issn=2073-4409}}</ref> ICAM3 mediates adhesion between cells by binding to specific integrin receptors.<ref name=":4">{{Cite journal |last=Cockram |first=Tom O. J. |last2=Dundee |first2=Jacob M. |last3=Popescu |first3=Alma S. |last4=Brown |first4=Guy C. |date=2021 |title=The Phagocytic Code Regulating Phagocytosis of Mammalian Cells |url=https://www.frontiersin.org/article/10.3389/fimmu.2021.629979 |journal=Frontiers in Immunology |volume=12 |doi=10.3389/fimmu.2021.629979/full |issn=1664-3224}}</ref> It plays an important role in the immune cell response through its facilitation of interactions between [[T cell|T cells]] and [[Dendritic cell|dendritic cells]], which allows for T cell activation.<ref name=":2">{{Cite journal |last=Svajger |first=Urban |last2=Anderluh |first2=Marko |last3=Jeras |first3=Matjaz |last4=Obermajer |first4=Natasa |date=2010-10 |title=C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity |url=https://pubmed.ncbi.nlm.nih.gov/20363321/ |journal=Cellular Signalling |volume=22 |issue=10 |pages=1397–1405 |doi=10.1016/j.cellsig.2010.03.018 |issn=1873-3913 |pmc=7127357 |pmid=20363321}}</ref><ref name=":22">{{Cite journal |last=Svajger |first=Urban |last2=Anderluh |first2=Marko |last3=Jeras |first3=Matjaz |last4=Obermajer |first4=Natasa |date=2010-10 |title=C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity |url=https://pubmed.ncbi.nlm.nih.gov/20363321/ |journal=Cellular Signalling |volume=22 |issue=10 |pages=1397–1405 |doi=10.1016/j.cellsig.2010.03.018 |issn=1873-3913 |pmc=7127357 |pmid=20363321}}</ref>
'''Intercellular adhesion molecule 3''' ('''ICAM3''') also known as '''CD50''' ('''C'''luster of '''D'''ifferentiation '''50'''), is a [[protein]] that in humans is encoded by the ''ICAM3'' [[gene]].<ref>{{Cite web |title=ICAM3 intercellular adhesion molecule 3 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/3385 |access-date=2022-03-10 |website=www.ncbi.nlm.nih.gov}}</ref> The protein is constitutively expressed on the surface of [[White blood cell|leukocytes]], which are also called white blood cells and are part of the immune system.<ref>{{Cite journal |last=Xiao |first=Xiang |last2=Mruk |first2=Dolores D. |last3=Cheng |first3=C. Yan |date=2013-3 |title=Intercellular adhesion molecules (ICAMs) and spermatogenesis |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576004/ |journal=Human Reproduction Update |volume=19 |issue=2 |pages=167–186 |doi=10.1093/humupd/dms049 |issn=1355-4786 |pmc=3576004 |pmid=23287428}}</ref><ref>{{Cite journal |last=Pastwińska |first=Joanna |last2=Żelechowska |first2=Paulina |last3=Walczak-Drzewiecka |first3=Aurelia |last4=Brzezińska-Błaszczyk |first4=Ewa |last5=Dastych |first5=Jarosław |date=2020-12 |title=The Art of Mast Cell Adhesion |url=https://www.mdpi.com/2073-4409/9/12/2664 |journal=Cells |language=en |volume=9 |issue=12 |pages=2664 |doi=10.3390/cells9122664 |issn=2073-4409}}</ref> ICAM3 mediates adhesion between cells by binding to specific integrin receptors.<ref name=":4">{{Cite journal |last=Cockram |first=Tom O. J. |last2=Dundee |first2=Jacob M. |last3=Popescu |first3=Alma S. |last4=Brown |first4=Guy C. |date=2021 |title=The Phagocytic Code Regulating Phagocytosis of Mammalian Cells |url=https://www.frontiersin.org/article/10.3389/fimmu.2021.629979 |journal=Frontiers in Immunology |volume=12 |doi=10.3389/fimmu.2021.629979/full |issn=1664-3224}}</ref> It plays an important role in the immune cell response through its facilitation of interactions between [[T cell|T cells]] and [[Dendritic cell|dendritic cells]], which allows for T cell activation.<ref name=":2">{{Cite journal |last=Svajger |first=Urban |last2=Anderluh |first2=Marko |last3=Jeras |first3=Matjaz |last4=Obermajer |first4=Natasa |date=2010-10 |title=C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity |url=https://pubmed.ncbi.nlm.nih.gov/20363321/ |journal=Cellular Signalling |volume=22 |issue=10 |pages=1397–1405 |doi=10.1016/j.cellsig.2010.03.018 |issn=1873-3913 |pmc=7127357 |pmid=20363321}}</ref><ref name=":22">{{Cite journal |last=Svajger |first=Urban |last2=Anderluh |first2=Marko |last3=Jeras |first3=Matjaz |last4=Obermajer |first4=Natasa |date=2010-10 |title=C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity |url=https://pubmed.ncbi.nlm.nih.gov/20363321/ |journal=Cellular Signalling |volume=22 |issue=10 |pages=1397–1405 |doi=10.1016/j.cellsig.2010.03.018 |issn=1873-3913 |pmc=7127357 |pmid=20363321}}</ref> ICAM3 also mediates the clearance of cells undergoing [[apoptosis]] by attracting and binding [[Macrophage|macrophages]], a type of cell that breaks down infected or dying cells through a process known as [[phagocytosis]], to apoptotic cells.<ref name=":42">{{Cite journal |last=Cockram |first=Tom O. J. |last2=Dundee |first2=Jacob M. |last3=Popescu |first3=Alma S. |last4=Brown |first4=Guy C. |date=2021 |title=The Phagocytic Code Regulating Phagocytosis of Mammalian Cells |url=https://www.frontiersin.org/article/10.3389/fimmu.2021.629979 |journal=Frontiers in Immunology |volume=12 |doi=10.3389/fimmu.2021.629979/full |issn=1664-3224}}</ref><ref name=":7">{{Citation |last=Numata |first=Yasunao |title=Apoptotic Cell Clearance in Gut Tissue: Role of Intestinal Regeneration |date=2018 |url=https://doi.org/10.1007/978-3-319-98146-8_6 |work=Autophagy in Health and Disease: Potential Therapeutic Approaches |pages=87–100 |editor-last=Turksen |editor-first=Kursad |series=Stem Cell Biology and Regenerative Medicine |place=Cham |publisher=Springer International Publishing |language=en |doi=10.1007/978-3-319-98146-8_6 |isbn=978-3-319-98146-8 |access-date=2022-03-09 |last2=Hirayama |first2=Daisuke |last3=Wagatsuma |first3=Kohei |last4=Iida |first4=Tomoya |last5=Nakase |first5=Hiroshi}}</ref><ref name=":8">{{Citation |last=Marek |first=Carylyn J. |title=Clearance of Apoptotic Cells – Mechanisms and Consequences |date=2009 |url=https://doi.org/10.1007/978-1-60327-381-7_11 |work=Essentials of Apoptosis: A Guide for Basic and Clinical Research |pages=261–282 |editor-last=Dong |editor-first=Zheng |place=Totowa, NJ |publisher=Humana Press |language=en |doi=10.1007/978-1-60327-381-7_11 |isbn=978-1-60327-381-7 |access-date=2022-03-09 |last2=Erwig |first2=Lars-Peter |editor2-last=Yin |editor2-first=Xiao-Ming}}</ref>


== Function ==
== Function ==

Revision as of 21:45, 10 March 2022

ICAM3
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesICAM3, CD50, CDW50, ICAM-R, intercellular adhesion molecule 3
External IDsOMIM: 146631 HomoloGene: 88479 GeneCards: ICAM3
Orthologs
SpeciesHumanMouse
Entrez

3385

n/a

Ensembl

ENSG00000076662

n/a

UniProt

P32942

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001307534
NP_001307535
NP_001307537
NP_002153

n/a

Location (UCSC)Chr 19: 10.33 – 10.34 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene.[3] The protein is constitutively expressed on the surface of leukocytes, which are also called white blood cells and are part of the immune system.[4][5] ICAM3 mediates adhesion between cells by binding to specific integrin receptors.[6] It plays an important role in the immune cell response through its facilitation of interactions between T cells and dendritic cells, which allows for T cell activation.[7][8] ICAM3 also mediates the clearance of cells undergoing apoptosis by attracting and binding macrophages, a type of cell that breaks down infected or dying cells through a process known as phagocytosis, to apoptotic cells.[9][10][11]

Function

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leukocytes and may be the most important ligand for LFA-1 in the initiation of the immune response.[12] It functions not only as an adhesion molecule, but also as a potent signalling molecule.[13]

Interactions

ICAM3 has been shown to interact with EZR[14][15] and Moesin.[15][16]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076662 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "ICAM3 intercellular adhesion molecule 3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-03-10.
  4. ^ Xiao, Xiang; Mruk, Dolores D.; Cheng, C. Yan (2013-3). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update. 19 (2): 167–186. doi:10.1093/humupd/dms049. ISSN 1355-4786. PMC 3576004. PMID 23287428. {{cite journal}}: Check date values in: |date= (help)
  5. ^ Pastwińska, Joanna; Żelechowska, Paulina; Walczak-Drzewiecka, Aurelia; Brzezińska-Błaszczyk, Ewa; Dastych, Jarosław (2020-12). "The Art of Mast Cell Adhesion". Cells. 9 (12): 2664. doi:10.3390/cells9122664. ISSN 2073-4409. {{cite journal}}: Check date values in: |date= (help)CS1 maint: unflagged free DOI (link)
  6. ^ Cockram, Tom O. J.; Dundee, Jacob M.; Popescu, Alma S.; Brown, Guy C. (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12. doi:10.3389/fimmu.2021.629979/full. ISSN 1664-3224.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  7. ^ Svajger, Urban; Anderluh, Marko; Jeras, Matjaz; Obermajer, Natasa (2010-10). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. ISSN 1873-3913. PMC 7127357. PMID 20363321. {{cite journal}}: Check date values in: |date= (help)
  8. ^ Svajger, Urban; Anderluh, Marko; Jeras, Matjaz; Obermajer, Natasa (2010-10). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. ISSN 1873-3913. PMC 7127357. PMID 20363321. {{cite journal}}: Check date values in: |date= (help)
  9. ^ Cockram, Tom O. J.; Dundee, Jacob M.; Popescu, Alma S.; Brown, Guy C. (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12. doi:10.3389/fimmu.2021.629979/full. ISSN 1664-3224.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  10. ^ Numata, Yasunao; Hirayama, Daisuke; Wagatsuma, Kohei; Iida, Tomoya; Nakase, Hiroshi (2018), Turksen, Kursad (ed.), "Apoptotic Cell Clearance in Gut Tissue: Role of Intestinal Regeneration", Autophagy in Health and Disease: Potential Therapeutic Approaches, Stem Cell Biology and Regenerative Medicine, Cham: Springer International Publishing, pp. 87–100, doi:10.1007/978-3-319-98146-8_6, ISBN 978-3-319-98146-8, retrieved 2022-03-09
  11. ^ Marek, Carylyn J.; Erwig, Lars-Peter (2009), Dong, Zheng; Yin, Xiao-Ming (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09
  12. ^ de Fougerolles AR, Springer TA (Jan 1992). "Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes". The Journal of Experimental Medicine. 175 (1): 185–90. doi:10.1084/jem.175.1.185. PMC 2119096. PMID 1730916.
  13. ^ "Entrez Gene: ICAM3 intercellular adhesion molecule 3".
  14. ^ Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (Aug 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". The Journal of Biological Chemistry. 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. PMID 9705328.
  15. ^ a b Serrador JM, Vicente-Manzanares M, Calvo J, Barreiro O, Montoya MC, Schwartz-Albiez R, Furthmayr H, Lozano F, Sánchez-Madrid F (Mar 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". The Journal of Biological Chemistry. 277 (12): 10400–9. doi:10.1074/jbc.M110694200. PMID 11784723.
  16. ^ Serrador JM, Alonso-Lebrero JL, del Pozo MA, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (Sep 1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization" (PDF). The Journal of Cell Biology. 138 (6): 1409–23. doi:10.1083/jcb.138.6.1409. PMC 2132557. PMID 9298994.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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