CD82 (gene)

CD82
Identifiers
Aliases	CD82, 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27, CD82 molecule
External IDs	OMIM: 600623; MGI: 104651; HomoloGene: 20512; GeneCards: CD82; OMA:CD82 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	44,620,358 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	93,293,485 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; beta cell; ; mucosa of esophagus; ; upper lobe of left lung; ; lymph node; ; olfactory zone of nasal mucosa; ; right lung; ; skin of abdomen; ; gallbladder; ; thoracic diaphragm;
	Top expressed in
	parotid gland; ; lacrimal gland; ; choroid plexus of fourth ventricle; ; granulocyte; ; tibiofemoral joint; ; fetal liver hematopoietic progenitor cell; ; submandibular gland; ; pyloric antrum; ; ileum; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	cell surface receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3732
	12521
	ENSG00000085117
	ENSMUSG00000027215
	P27701
	P40237
	NM_001024844; NM_002231
NM_001136055; NM_001271430; NM_001271431; NM_001271432; NM_001271461;
	NM_001271462; NM_007656
	NP_001020015; NP_002222
NP_001129527; NP_001258359; NP_001258360; NP_001258361; NP_001258390;
	NP_001258391; NP_031682
	Wikidata
View/Edit Human	View/Edit Mouse

CD82 (Cluster of Differentiation 82) is a human protein encoded by the CD82 gene.^[5]

Template:PBB Summary

Interactions

CD82 (gene) has been shown to interact with CD19,^[6]^[7] CD63^[8] and CD234^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000085117 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027215 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD82 CD82 molecule".
^ Imai, T; Kakizaki M; Nishimura M; Yoshie O (August 1995). "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". J. Immunol. 155 (3). UNITED STATES: 1229–39. ISSN 0022-1767. PMID 7636191. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Horváth, G; Serru V; Clay D; Billard M; Boucheix C; Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". J. Biol. Chem. 273 (46). UNITED STATES: 30537–43. doi:10.1074/jbc.273.46.30537. ISSN 0021-9258. PMID 9804823. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Hammond, C; Denzin L K; Pan M; Griffith J M; Geuze H J; Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". J. Immunol. 161 (7). UNITED STATES: 3282–91. ISSN 0022-1767. PMID 9759843. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)
^ Hur, Jin; Choi, Jae-Il; Lee, Hwan; Nham, Pniel; Kim, Tae-Won; Chae, Cheong-Whan; Yun, Ji-Yeon; Kang, Jin-A.; Kang, Jeehoon (2016-04-07). "CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages". Cell Stem Cell. 18 (4): 508–521. doi:10.1016/j.stem.2016.01.013. ISSN 1875-9777. PMID 26996598.

External links

CD82+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD82 genome location and CD82 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085117 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027215 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD82 CD82 molecule".

[pmid7636191-6] Imai, T; Kakizaki M; Nishimura M; Yoshie O (August 1995). "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". J. Immunol. 155 (3). UNITED STATES: 1229–39. ISSN 0022-1767. PMID 7636191. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid9804823-7] Horváth, G; Serru V; Clay D; Billard M; Boucheix C; Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". J. Biol. Chem. 273 (46). UNITED STATES: 30537–43. doi:10.1074/jbc.273.46.30537. ISSN 0021-9258. PMID 9804823. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

[pmid9759843-8] Hammond, C; Denzin L K; Pan M; Griffith J M; Geuze H J; Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". J. Immunol. 161 (7). UNITED STATES: 3282–91. ISSN 0022-1767. PMID 9759843. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)

[9] Hur, Jin; Choi, Jae-Il; Lee, Hwan; Nham, Pniel; Kim, Tae-Won; Chae, Cheong-Whan; Yun, Ji-Yeon; Kang, Jin-A.; Kang, Jeehoon (2016-04-07). "CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages". Cell Stem Cell. 18 (4): 508–521. doi:10.1016/j.stem.2016.01.013. ISSN 1875-9777. PMID 26996598.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

CD82 (gene)

Interactions

See also

References

Further reading

External links