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{{About|the molecule|the compilation album|CD86 (album)}}
{{About|the molecule|the compilation album|CD86 (album)}}
{{PBB|geneid=942}}
{{PBB|geneid=942}}
'''Cluster of Differentiation 86''' (also '''CD86''' and '''B7-2''') is a protein expressed on [[antigen-presenting cells]] that provides costimulatory signals necessary for [[T cell]] activation and survival. It is the [[ligand (biochemistry)|ligand]] for two different proteins on the T cell surface: [[CD28]] (for autoregulation and intercellular association) and [[CTLA-4]] (for attenuation of regulation and cellular disassociation). CD86 works in tandem with [[CD80]] to prime T cells.
'''Cluster of Differentiation 86''' (also known as '''CD86''' and '''B7-2''') is a [[protein]] expressed on [[antigen-presenting cells]] that provides costimulatory signals necessary for [[T cell]] activation and survival. It is the [[ligand (biochemistry)|ligand]] for two different proteins on the T cell surface: [[CD28]] (for autoregulation and intercellular association) and [[CTLA-4]] (for attenuation of regulation and cellular disassociation). CD86 works in tandem with [[CD80]] to prime T cells.


The ''CD86'' gene encodes a type I membrane protein that is a member of the [[immunoglobulin]] superfamily. [[Alternative splicing]] results in two transcript variants encoding different [[protein isoform|isoform]]s. Additional transcript variants have been described, but their full-length sequences have not been determined.<ref>{{cite web | title = Entrez Gene: CD86 CD86 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=942| accessdate = }}</ref>
The ''CD86'' [[gene]] encodes a type I membrane protein that is a member of the [[immunoglobulin]] superfamily.<ref name="pmid7513726">{{cite journal | author = Chen C, Gault A, Shen L, Nabavi N | title = Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule | journal = J. Immunol. | volume = 152 | issue = 10 | pages = 4929–36 | year = 1994 | month = May | pmid = 7513726 | doi = | url = | issn = }}</ref> [[Alternative splicing]] results in two transcript variants encoding different [[protein isoform|isoform]]s. Additional transcript variants have been described, but their full-length sequences have not been determined.<ref>{{cite web | title = Entrez Gene: CD86 CD86 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=942| accessdate = }}</ref>


== Clinical significance ==
Recent studies indicate that CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.

CD86+ [[macrophage]]s in [[Hodgkin lymphoma]] patients are an independent marker for potential nonresponse to firstline-therapy.<ref name="pmid20220182">{{cite journal | author = Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, Delaney A, Jones SJ, Iqbal J, Weisenburger DD, Bast MA, Rosenwald A, Muller-Hermelink HK, Rimsza LM, Campo E, Delabie J, Braziel RM, Cook JR, Tubbs RR, Jaffe ES, Lenz G, Connors JM, Staudt LM, Chan WC, Gascoyne RD | title = Tumor-associated macrophages and survival in classic Hodgkin's lymphoma | journal = N. Engl. J. Med. | volume = 362 | issue = 10 | pages = 875–85 | year = 2010 | month = March | pmid = 20220182 | pmc = 2897174 | doi = 10.1056/NEJMoa0905680 | url = | issn = }}</ref>


==See also==
==See also==
Line 15: Line 17:
==References==
==References==
{{Reflist}}
{{Reflist}}
Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. on pubmed.com


==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal |author=Davila S, Froeling FE, Tan A, ''et al.'' |title=New genetic associations detected in a host response study to hepatitis B vaccine. |journal=Genes Immun. |volume=11 |issue= 3 |pages= 232-8 |year= 2010 |pmid= 20237496 |doi= 10.1038/gene.2010.1 }}
{{PBB_Further_reading
*{{cite journal |author=Csillag A, Boldogh I, Pazmandi K, ''et al.'' |title=Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions. |journal=J. Immunol. |volume=184 |issue= 5 |pages= 2377-85 |year= 2010 |pmid= 20118277 |doi= 10.4049/jimmunol.0803938 }}
| citations =
*{{cite journal |author=Bossé Y, Lemire M, Poon AH, ''et al.'' |title=Asthma and genes encoding components of the vitamin D pathway. |journal=Respir. Res. |volume=10 |issue= |pages= 98 |year= 2009 |pmid= 19852851 |doi= 10.1186/1465-9921-10-98 }}
}}
*{{cite journal |author=Mosbruger TL, Duggal P, Goedert JJ, ''et al.'' |title=Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. |journal=J. Infect. Dis. |volume=201 |issue= 9 |pages= 1371-80 |year= 2010 |pmid= 20331378 |doi= 10.1086/651606 }}
*{{cite journal |author=Bugeon L, Dallman MJ |title=Costimulation of T cells. |journal=Am. J. Respir. Crit. Care Med. |volume=162 |issue= 4 Pt 2 |pages= S164-8 |year= 2000 |pmid= 11029388 |doi= }}
*{{cite journal |author=Pan XM, Gao LB, Liang WB, ''et al.'' |title=CD86 +1057 G/A polymorphism and the risk of colorectal cancer. |journal=DNA Cell Biol. |volume=29 |issue= 7 |pages= 381-6 |year= 2010 |pmid= 20380573 |doi= 10.1089/dna.2009.1003 }}
*{{cite journal |author=Dalla-Costa R, Pincerati MR, Beltrame MH, ''et al.'' |title=Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus. |journal=Hum. Immunol. |volume=71 |issue= 8 |pages= 809-17 |year= 2010 |pmid= 20433886 |doi= 10.1016/j.humimm.2010.04.001 }}
*{{cite journal |author=Talmud PJ, Drenos F, Shah S, ''et al.'' |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |journal=Am. J. Hum. Genet. |volume=85 |issue= 5 |pages= 628-42 |year= 2009 |pmid= 19913121 |doi= 10.1016/j.ajhg.2009.10.014 }}
*{{cite journal |author=Carreño LJ, Pacheco R, Gutierrez MA, ''et al.'' |title=Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells. |journal=Immunology |volume=128 |issue= 3 |pages= 334-41 |year= 2009 |pmid= 20067533 |doi= 10.1111/j.1365-2567.2009.03138.x }}
*{{cite journal |author=Koyasu S |title=The role of PI3K in immune cells. |journal=Nat. Immunol. |volume=4 |issue= 4 |pages= 313-9 |year= 2003 |pmid= 12660731 |doi= 10.1038/ni0403-313 }}
*{{cite journal |author=Kim SH, Lee JE, Kim SH, ''et al.'' |title=Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions. |journal=Clin. Exp. Allergy |volume=39 |issue= 12 |pages= 1852-6 |year= 2009 |pmid= 19735272 |doi= 10.1111/j.1365-2222.2009.03336.x }}
*{{cite journal |author=Liu Y, Liang WB, Gao LB, ''et al.'' |title=CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. |journal=Hum. Immunol. |volume=71 |issue= 11 |pages= 1141-6 |year= 2010 |pmid= 20732370 |doi= 10.1016/j.humimm.2010.08.007 }}
*{{cite journal |author=Ma XN, Wang X, Yan YY, ''et al.'' |title=Absence of association between CD86 +1057G/A polymorphism and coronary artery disease. |journal=DNA Cell Biol. |volume=29 |issue= 6 |pages= 325-8 |year= 2010 |pmid= 20230296 |doi= 10.1089/dna.2009.0987 }}
*{{cite journal |author=Ishizaki Y, Yukaya N, Kusuhara K, ''et al.'' |title=PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. |journal=Human genetics |volume= |issue= |pages= HASH(0x31b6c40) |year= 2010 |pmid= 20066438 |doi= 10.1007/s00439-009-0781-z }}
*{{cite journal |author=Chang TT, Kuchroo VK, Sharpe AH |title=Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. |journal=Curr. Dir. Autoimmun. |volume=5 |issue= |pages= 113-30 |year= 2002 |pmid= 11826754 |doi= }}
*{{cite journal |author=Grujic M, Bartholdy C, Remy M, ''et al.'' |title=The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus. |journal=J. Immunol. |volume=185 |issue= 3 |pages= 1730-43 |year= 2010 |pmid= 20601595 |doi= 10.4049/jimmunol.0903894 }}
*{{cite journal |author=Quaranta MG, Mattioli B, Giordani L, Viora M |title=The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS. |journal=FASEB J. |volume=20 |issue= 13 |pages= 2198-208 |year= 2006 |pmid= 17077296 |doi= 10.1096/fj.06-6260rev }}
*{{cite journal |author=Schuurhof A, Bont L, Siezen CL, ''et al.'' |title=Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. |journal=Pediatr. Pulmonol. |volume=45 |issue= 6 |pages= 608-13 |year= 2010 |pmid= 20503287 |doi= 10.1002/ppul.21229 }}
*{{cite journal |author=Bailey SD, Xie C, Do R, ''et al.'' |title=Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |journal=Diabetes Care |volume=33 |issue= 10 |pages= 2250-3 |year= 2010 |pmid= 20628086 |doi= 10.2337/dc10-0452 }}
*{{cite journal |author=Radziewicz H, Ibegbu CC, Hon H, ''et al.'' |title=Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling. |journal=J. Immunol. |volume=184 |issue= 5 |pages= 2410-22 |year= 2010 |pmid= 20100932 |doi= 10.4049/jimmunol.0902994 }}
{{refend}}
{{refend}}

{{PDB Gallery|geneid=942}}
{{PDB Gallery|geneid=942}}

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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]


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Revision as of 22:07, 31 October 2010

This article is about the molecule. For the compilation album, see CD86 (album).

Template:PBB Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.[1] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.[2]

Clinical significance

CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.[3]

See also

References

  1. ^ Chen C, Gault A, Shen L, Nabavi N (1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ "Entrez Gene: CD86 CD86 molecule".
  3. ^ Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, Delaney A, Jones SJ, Iqbal J, Weisenburger DD, Bast MA, Rosenwald A, Muller-Hermelink HK, Rimsza LM, Campo E, Delabie J, Braziel RM, Cook JR, Tubbs RR, Jaffe ES, Lenz G, Connors JM, Staudt LM, Chan WC, Gascoyne RD (2010). "Tumor-associated macrophages and survival in classic Hodgkin's lymphoma". N. Engl. J. Med. 362 (10): 875–85. doi:10.1056/NEJMoa0905680. PMC 2897174. PMID 20220182. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Further reading

  • Davila S, Froeling FE, Tan A; et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Csillag A, Boldogh I, Pazmandi K; et al. (2010). "Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions". J. Immunol. 184 (5): 2377–85. doi:10.4049/jimmunol.0803938. PMID 20118277. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Bossé Y, Lemire M, Poon AH; et al. (2009). "Asthma and genes encoding components of the vitamin D pathway". Respir. Res. 10: 98. doi:10.1186/1465-9921-10-98. PMID 19852851. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Mosbruger TL, Duggal P, Goedert JJ; et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMID 20331378. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Bugeon L, Dallman MJ (2000). "Costimulation of T cells". Am. J. Respir. Crit. Care Med. 162 (4 Pt 2): S164-8. PMID 11029388.
  • Pan XM, Gao LB, Liang WB; et al. (2010). "CD86 +1057 G/A polymorphism and the risk of colorectal cancer". DNA Cell Biol. 29 (7): 381–6. doi:10.1089/dna.2009.1003. PMID 20380573. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Dalla-Costa R, Pincerati MR, Beltrame MH; et al. (2010). "Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus". Hum. Immunol. 71 (8): 809–17. doi:10.1016/j.humimm.2010.04.001. PMID 20433886. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Talmud PJ, Drenos F, Shah S; et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Carreño LJ, Pacheco R, Gutierrez MA; et al. (2009). "Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells". Immunology. 128 (3): 334–41. doi:10.1111/j.1365-2567.2009.03138.x. PMID 20067533. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731.
  • Kim SH, Lee JE, Kim SH; et al. (2009). "Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions". Clin. Exp. Allergy. 39 (12): 1852–6. doi:10.1111/j.1365-2222.2009.03336.x. PMID 19735272. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Liu Y, Liang WB, Gao LB; et al. (2010). "CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease". Hum. Immunol. 71 (11): 1141–6. doi:10.1016/j.humimm.2010.08.007. PMID 20732370. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Ma XN, Wang X, Yan YY; et al. (2010). "Absence of association between CD86 +1057G/A polymorphism and coronary artery disease". DNA Cell Biol. 29 (6): 325–8. doi:10.1089/dna.2009.0987. PMID 20230296. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Ishizaki Y, Yukaya N, Kusuhara K; et al. (2010). "PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis". Human genetics: HASH(0x31b6c40). doi:10.1007/s00439-009-0781-z. PMID 20066438. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Curr. Dir. Autoimmun. 5: 113–30. PMID 11826754.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Grujic M, Bartholdy C, Remy M; et al. (2010). "The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus". J. Immunol. 185 (3): 1730–43. doi:10.4049/jimmunol.0903894. PMID 20601595. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Schuurhof A, Bont L, Siezen CL; et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13. doi:10.1002/ppul.21229. PMID 20503287. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Bailey SD, Xie C, Do R; et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMID 20628086. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Radziewicz H, Ibegbu CC, Hon H; et al. (2010). "Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling". J. Immunol. 184 (5): 2410–22. doi:10.4049/jimmunol.0902994. PMID 20100932. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)

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