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P2RY6

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(Redirected from P2RY6 (gene))
P2RY6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesP2RY6, P2Y6, pyrimidinergic receptor P2Y6
External IDsOMIM: 602451; MGI: 2673874; HomoloGene: 14289; GeneCards: P2RY6; OMA:P2RY6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_183168

RefSeq (protein)

NP_898991

Location (UCSC)Chr 11: 73.26 – 73.31 MbChr 7: 100.59 – 100.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.[5][6]

Function

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The product of this gene, P2Y6, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171631Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048779Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Communi D, Parmentier M, Boeynaems JM (May 1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor". Biochemical and Biophysical Research Communications. 222 (2): 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200.
  6. ^ a b "Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6".

Further reading

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  • "P2Y Receptors: P2Y6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2015-02-17. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.