This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.
^Koch-Nolte F, Haag F, Braren R, Kuhl M, Hoovers J, Balasubramanian S, Bazan F, Thiele HG (Apr 1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins". Genomics39 (3): 370–6. doi:10.1006/geno.1996.4520. PMID9119374.
Mauthe J, Coghlan G, Zelinski T (2000). "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2". Vox Sang.79 (1): 53–6. doi:10.1046/j.1423-0410.2000.7910053.x. PMID10971215.
Gubin AN; Njoroge JM; Wojda U et al. (2000). "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family". Blood96 (7): 2621–7. PMID11001920.Cite uses deprecated parameter |author-separator= (help)
Wu GG, Jin SZ, Deng ZH, Zhao TM (2002). "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors". Vox Sang.81 (1): 49–51. doi:10.1046/j.1423-0410.2001.00052.x. PMID11520417.
Grahnert A, Friedrich M, Engeland K, Hauschildt S (2005). "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements". Biochim. Biophys. Acta1730 (3): 173–86. doi:10.1016/j.bbaexp.2005.08.001. PMID16140404.