GP1BA

GP1BA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GWB, 1M0Z, 1M10, 1OOK, 1P8V, 1P9A, 1QYY, 1SQ0, 1U0N, 2BP3, 3P72, 3PMH, 4C2A, 4C2B, 4CH2, 4CH8, 4MGX, 4YR6
Identifiers
Aliases	GP1BA, BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, GPIbalpha, glycoprotein Ib platelet alpha subunit, glycoprotein Ib platelet subunit alpha
External IDs	OMIM: 606672; MGI: 1333744; HomoloGene: 143; GeneCards: GP1BA; OMA:GP1BA - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.2 Start 4,932,277 bp End 4,935,023 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B3|11 43.2 cM Start 70,529,948 bp End 70,532,862 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte lymph node buccal mucosa cell secondary oocyte trabecular bone granulocyte blood bone marrow cells mucosa of ileum tibialis anterior muscle Top expressed in blood tibiofemoral joint granulocyte embryo muscle of thigh neural layer of retina yolk sac morula spleen lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase inhibitor activity thrombin-activated receptor activity protein binding Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane cell surface anchored component of external side of plasma membrane extracellular exosome extracellular space extracellular matrix Biological process blood coagulation, intrinsic pathway hemostasis fibrinolysis negative regulation of protein kinase activity cytokine-mediated signaling pathway blood coagulation platelet activation cell surface receptor signaling pathway cell adhesion cell morphogenesis regulation of blood coagulation negative regulation of receptor signaling pathway via JAK-STAT thrombin-activated receptor signaling pathway platelet aggregation regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2811 14723 Ensembl ENSG00000185245 ENSMUSG00000050675 UniProt P07359 O35930 RefSeq (mRNA) NM_000173 NM_010326 RefSeq (protein) NP_000164 NP_034456 Location (UCSC) Chr 17: 4.93 – 4.94 Mb Chr 11: 70.53 – 70.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene.

Function

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard–Soulier syndromes and platelet-type von Willebrand disease.

Interactions

GP1BA has been shown to interact with YWHAZ and FLNB.

See also

• Cluster of differentiation

Further reading

• Kunishima S, Kamiya T, Saito H (2002). "Genetic abnormalities of Bernard-Soulier syndrome". Int. J. Hematol. 76 (4): 319–27. doi:10.1007/BF02982690. PMID 12463594. S2CID 23635810.
• Du X (2007). "Signaling and regulation of the platelet glycoprotein Ib-IX-V complex". Curr. Opin. Hematol. 14 (3): 262–9. doi:10.1097/MOH.0b013e3280dce51a. PMID 17414217. S2CID 39904506.
• Clemetson KJ (2007). "A short history of platelet glycoprotein Ib complex". Thromb. Haemost. 98 (1): 63–8. doi:10.1160/th07-05-0327. PMID 17597992.
• López JA, Ludwig EH, McCarthy BJ (1992). "Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications". J. Biol. Chem. 267 (14): 10055–61. doi:10.1016/S0021-9258(19)50199-5. PMID 1577776.
• Murata M, Furihata K, Ishida F, Russell SR, Ware J, Ruggeri ZM (1992). "Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness". Blood. 79 (11): 3086–90. doi:10.1182/blood.V79.11.3086.3086. PMID 1586750.
• Girma JP, Takahashi Y, Yoshioka A, Diaz J, Meyer D (1990). "Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib". Thromb. Haemost. 64 (2): 326–32. doi:10.1055/s-0038-1647310. PMID 1702906.
• Miller JL, Lyle VA, Cunningham D (1992). "Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease". Blood. 79 (2): 439–46. doi:10.1182/blood.V79.2.439.439. PMID 1730088.
• Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE (1992). "Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane". J. Biol. Chem. 267 (1): 364–9. doi:10.1016/S0021-9258(18)48503-1. PMID 1730602.
• Miller JL, Cunningham D, Lyle VA, Finch CN (1991). "Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease". Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4761–5. Bibcode:1991PNAS...88.4761M. doi:10.1073/pnas.88.11.4761. PMC 51746. PMID 2052556.
• Hess D, Schaller J, Rickli EE, Clemetson KJ (1991). "Identification of the disulphide bonds in human platelet glycocalicin". Eur. J. Biochem. 199 (2): 389–93. doi:10.1111/j.1432-1033.1991.tb16135.x. PMID 2070794.
• Du X, Beutler L, Ruan C, Castaldi PA, Berndt MC (1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524–7. doi:10.1182/blood.V69.5.1524.1524. PMID 2436691.
• Andrews RK, Booth WJ, Gorman JJ, Castaldi PA, Berndt MC (1989). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry. 28 (21): 8317–26. doi:10.1021/bi00447a009. PMID 2557900.
• Wenger RH, Wicki AN, Kieffer N, Adolph S, Hameister H, Clemetson KJ (1989). "The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha". Gene. 85 (2): 517–24. doi:10.1016/0378-1119(89)90446-0. PMID 2628181.
• Wenger RH, Kieffer N, Wicki AN, Clemetson KJ (1988). "Structure of the human blood platelet membrane glycoprotein Ib alpha gene". Biochem. Biophys. Res. Commun. 156 (1): 389–95. doi:10.1016/S0006-291X(88)80853-2. PMID 2845978.
• Wicki AN, Clemetson KJ (1985). "Structure and function of platelet membrane glycoproteins Ib and V. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin". Eur. J. Biochem. 153 (1): 1–11. doi:10.1111/j.1432-1033.1985.tb09259.x. PMID 2933256.
• Adelman B, Michelson AD, Greenberg J, Handin RI (1986). "Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions". Blood. 68 (6): 1280–4. doi:10.1182/blood.V68.6.1280.1280. PMID 2946332.
• Lopez JA, Chung DW, Fujikawa K, Hagen FS, Papayannopoulou T, Roth GJ (1987). "Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein". Proc. Natl. Acad. Sci. U.S.A. 84 (16): 5615–9. Bibcode:1987PNAS...84.5615L. doi:10.1073/pnas.84.16.5615. PMC 298913. PMID 3303030.
• Lopez JA, Chung DW, Fujikawa K, Hagen FS, Davie EW, Roth GJ (1988). "The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2135–9. Bibcode:1988PNAS...85.2135L. doi:10.1073/pnas.85.7.2135. PMC 279943. PMID 3353370.
• Titani K, Takio K, Handa M, Ruggeri ZM (1987). "Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib". Proc. Natl. Acad. Sci. U.S.A. 84 (16): 5610–4. Bibcode:1987PNAS...84.5610T. doi:10.1073/pnas.84.16.5610. PMC 298912. PMID 3497398.
• Harmon JT, Jamieson GA (1986). "The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets". J. Biol. Chem. 261 (28): 13224–9. doi:10.1016/S0021-9258(18)69294-4. PMID 3759960.

External links

• GP1BA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.