CD46: Difference between revisions
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The protein encoded by this gene is a type I membrane protein and is a regulatory part of the [[complement system]]. |
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the [[complement system]]. |
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The encoded protein has cofactor activity for inactivation of complement components [[C3b]] and [[C4b]] by serum factor I, which protects the host cell from damage by complement. |
The encoded protein has cofactor activity for inactivation of complement components [[C3b]] and [[C4b]] by serum factor I, which protects the host cell from damage by complement.<ref name="pmid15324743">{{cite journal | author = Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP | title = CD46: expanding beyond complement regulation | journal = Trends Immunol. | volume = 25 | issue = 9 | pages = 496–503 | year = 2004 | month = September | pmid = 15324743 | doi = 10.1016/j.it.2004.07.004 | url = | issn = }}</ref> |
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The protein encoded by this gene may be involved in the fusion of the [[spermatozoa]] with the [[oocyte]] during fertilization. |
The protein encoded by this gene may be involved in the fusion of the [[spermatozoa]] with the [[oocyte]] during fertilization.<ref name="pmid16200405">{{cite journal | author = Liszewski MK, Kemper C, Price JD, Atkinson JP | title = Emerging roles and new functions of CD46 | journal = Springer Semin. Immunopathol. | volume = 27 | issue = 3 | pages = 345–58 | year = 2005 | month = November | pmid = 16200405 | doi = 10.1007/s00281-005-0002-3 | url = | issn = }}</ref> |
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== Clinical signficance == |
== Clinical signficance == |
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==References== |
==References== |
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==External links== |
==External links== |
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Revision as of 20:36, 3 January 2009
Template:PBB CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) is a protein which in humans is encoded by the CD46 gene.[1] CD46 is an inhibitory complement receptor.[2]
Gene
This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.[3]
Function
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system.
The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement.[4]
The protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization.[5]
Clinical signficance
The encoded protein can act as a receptor for the Edmonston strain of measles virus,[6] human herpesvirus-6, and type IV pili of pathogenic Neisseria.[7]
References
- ^ Taylor CT, Biljan MM, Kingsland CR, Johnson PM (1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)". Hum. Reprod. 9 (5): 907–11. PMID 7929741.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster". Annu. Rev. Immunol. 9: 431–55. doi:10.1146/annurev.iy.09.040191.002243. PMID 1910685.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: CD46 CD46 molecule, complement regulatory protein".
- ^ Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP (2004). "CD46: expanding beyond complement regulation". Trends Immunol. 25 (9): 496–503. doi:10.1016/j.it.2004.07.004. PMID 15324743.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Liszewski MK, Kemper C, Price JD, Atkinson JP (2005). "Emerging roles and new functions of CD46". Springer Semin. Immunopathol. 27 (3): 345–58. doi:10.1007/s00281-005-0002-3. PMID 16200405.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Dörig RE, Marcil A, Richardson CD (1994). "CD46, a primate-specific receptor for measles virus". Trends Microbiol. 2 (9): 312–8. PMID 7529121.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Cattaneo R (2004). "Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet". J. Virol. 78 (9): 4385–8. doi:10.1128/JVI.78.9.4385-4388.2004. PMC 387720. PMID 15078919.
{{cite journal}}: Unknown parameter|month=ignored (help)
External links
- CD46+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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