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Interleukin 13 receptor, alpha 1

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(Redirected from IL-13Rα1)
IL13RA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL13RA1, CD213A1, IL-13Ra, NR4, CT19, interleukin 13 receptor subunit alpha 1
External IDsOMIM: 300119; MGI: 105052; HomoloGene: 1198; GeneCards: IL13RA1; OMA:IL13RA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001560

NM_133990

RefSeq (protein)

NP_001551

NP_598751

Location (UCSC)Chr X: 118.73 – 118.79 MbChr X: 35.38 – 35.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene.[5]

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.[5]

IL13RA1 expression has been linked to higher survival rates for lung cancer patients.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131724Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017057Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL13RA1 interleukin 13 receptor, alpha 1".
  6. ^ "Research update from the MCM team (November 2023)". World Community Grid. 27 November 2023. Retrieved 21 May 2024.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.