TNFRSF12A

TNFRSF12A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EQP, 2KMZ, 2RPJ
Identifiers
Aliases	TNFRSF12A, CD266, FN14, TWEAKR, tumor necrosis factor receptor superfamily member 12A, TNF receptor superfamily member 12A
External IDs	OMIM: 605914; MGI: 1351484; HomoloGene: 8451; GeneCards: TNFRSF12A; OMA:TNFRSF12A - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,022,383 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	23,896,442 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; ascending aorta; ; body of pancreas; ; beta cell; ; anterior pituitary; ; gallbladder; ; right coronary artery; ; upper lobe of left lung; ; left ventricle; ; Descending thoracic aorta;
	Top expressed in
	interventricular septum; ; decidua; ; muscle of thigh; ; adrenal gland; ; soleus muscle; ; endothelial cell of lymphatic vessel; ; lip; ; yolk sac; ; right ventricle; ; gastrula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	ruffle; integral component of membrane; cell surface; plasma membrane; membrane;
Biological process	apoptotic process; substrate-dependent cell migration, cell attachment to substrate; multicellular organism development; positive regulation of extrinsic apoptotic signaling pathway; cell differentiation; positive regulation of axon extension; cell adhesion; tumor necrosis factor-mediated signaling pathway; regulation of wound healing; regulation of angiogenesis; extrinsic apoptotic signaling pathway; angiogenesis; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	51330
	27279
	ENSG00000006327
	ENSMUSG00000023905
	Q9NP84
	Q9CR75
	NM_016639
	NM_001161746; NM_013749
	NP_057723
	NP_001155218; NP_038777
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006327 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023905 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA (Jun 2000). "The Fn14 Immediate-Early Response Gene Is Induced During Liver Regeneration and Highly Expressed in Both Human and Murine Hepatocellular Carcinomas". Am J Pathol. 156 (4): 1253–61. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351.
^ Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA (Jan 2000). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". J Biol Chem. 274 (46): 33166–76. doi:10.1074/jbc.274.46.33166. PMID 10551889.
^ "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A".

Campbell S, Michaelson J, Burkly L, Putterman C (2006). "The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity" (PDF). Front. Biosci. 9 (1–3): 2273–2284. doi:10.2741/1395. PMID 15353286. S2CID 29249853. Archived from the original (PDF) on 2019-02-16.
Wiley SR, Cassiano L, Lofton T, et al. (2001). "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis". Immunity. 15 (5): 837–46. doi:10.1016/S1074-7613(01)00232-1. PMID 11728344.
Harada N, Nakayama M, Nakano H, et al. (2003). "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells". Biochem. Biophys. Res. Commun. 299 (3): 488–93. doi:10.1016/S0006-291X(02)02670-0. PMID 12445828.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Ishidoh K, Kojima Y, et al. (2003). "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death". J. Immunol. 170 (1): 341–8. doi:10.4049/jimmunol.170.1.341. PMID 12496418.
Tran NL, McDonough WS, Donohue PJ, et al. (2003). "The Human Fn14 Receptor Gene Is Up-Regulated in Migrating Glioma Cells in Vitro and Overexpressed in Advanced Glial Tumors". Am. J. Pathol. 162 (4): 1313–21. doi:10.1016/S0002-9440(10)63927-2. PMC 1851233. PMID 12651623.
Tanabe K, Bonilla I, Winkles JA, Strittmatter SM (2003). "Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth". J. Neurosci. 23 (29): 9675–86. doi:10.1523/JNEUROSCI.23-29-09675.2003. PMC 6740475. PMID 14573547.
Jin L, Nakao A, Nakayama M, et al. (2004). "Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes". J. Invest. Dermatol. 122 (5): 1175–9. doi:10.1111/j.0022-202X.2004.22419.x. PMID 15140220.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tran NL, McDonough WS, Savitch BA, et al. (2005). "The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression". J. Biol. Chem. 280 (5): 3483–92. doi:10.1074/jbc.M409906200. PMID 15611130.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chacón MR, Richart C, Gómez JM, et al. (2006). "Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity". Cytokine. 33 (3): 129–37. doi:10.1016/j.cyto.2005.12.005. PMID 16503147.
Brown SA, Hanscom HN, Vu H, et al. (2006). "TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules". Biochem. J. 397 (2): 297–304. doi:10.1042/BJ20051362. PMC 1513280. PMID 16526941.
Muñoz-García B, Martín-Ventura JL, Martínez E, et al. (2006). "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin". Stroke. 37 (8): 2044–53. doi:10.1161/01.STR.0000230648.00027.00. PMID 16809572.
Tran NL, McDonough WS, Savitch BA, et al. (2007). "Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome". Cancer Res. 66 (19): 9535–42. doi:10.1158/0008-5472.CAN-06-0418. PMID 17018610.
Girgenrath M, Weng S, Kostek CA, et al. (2007). "TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration". EMBO J. 25 (24): 5826–39. doi:10.1038/sj.emboj.7601441. PMC 1698888. PMID 17124496.
Dogra C, Hall SL, Wedhas N, et al. (2007). "Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis". J. Biol. Chem. 282 (20): 15000–10. doi:10.1074/jbc.M608668200. PMC 4149055. PMID 17383968.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006327 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023905 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10751351-5] Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA (Jun 2000). "The Fn14 Immediate-Early Response Gene Is Induced During Liver Regeneration and Highly Expressed in Both Human and Murine Hepatocellular Carcinomas". Am J Pathol. 156 (4): 1253–61. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351.

[pmid10551889-6] Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA (Jan 2000). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". J Biol Chem. 274 (46): 33166–76. doi:10.1074/jbc.274.46.33166. PMID 10551889.

[entrez-7] "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

References

Further reading