Prostaglandin F receptor
Template:PBB Prostaglandin F receptor (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.[1]
It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.
Two transcript variants encoding different isoforms have been found for this gene.[1]
Functions
Main effects of prostaglandin binding to the receptor are:
- uterine contraction
- bronchoconstriction[2]
Via activation of this receptor, PGF2-alpha mediates luteolysis,[1] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.[3]
Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[4]
See also
References
- ^ a b c "Entrez Gene: PTGFR prostaglandin F receptor (FP)".
- ^ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003) Page 234
- ^ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
- ^ Sugimoto Y; Yamasaki A; Segi E; et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science. 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889.
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External links
- "Prostanoid Receptors: FP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.