Prostacyclin receptor

PTGIR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F8K
Identifiers
Aliases	PTGIR, IP, PRIPR, prostaglandin I2 (prostacyclin) receptor (IP), prostaglandin I2 receptor
External IDs	OMIM: 600022; MGI: 99535; HomoloGene: 7496; GeneCards: PTGIR; OMA:PTGIR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	46,625,089 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,644,830 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; Descending thoracic aorta; ; right coronary artery; ; left coronary artery; ; upper lobe of left lung; ; monocyte; ; tibial arteries; ; apex of heart; ; right auricle; ; right lung;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; blood; ; trigeminal ganglion; ; ankle; ; intercostal muscle; ; mesenteric lymph nodes; ; embryo; ; endothelial cell of lymphatic vessel; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; guanyl-nucleotide exchange factor activity; prostacyclin receptor activity;
Cellular component	integral component of membrane; cytosol; plasma membrane; integral component of plasma membrane; membrane;
Biological process	negative regulation of platelet-derived growth factor receptor signaling pathway; cell-cell signaling; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; response to lipopolysaccharide; negative regulation of smooth muscle cell proliferation; adenylate cyclase-activating G protein-coupled receptor signaling pathway; signal transduction; G protein-coupled receptor signaling pathway; inflammatory response; positive regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	5739
	19222
	ENSG00000160013
	ENSMUSG00000043017
	P43119
	P43252
	NM_000960
	NM_008967
	NP_000951
	NP_032993
	Wikidata
View/Edit Human	View/Edit Mouse

Prostacyclin receptor is a receptor for prostacyclin (a prostaglandin that is also called prostaglandin I₂, PGI₂). Its HGNC name is prostaglandin I2 (prostacyclin) receptor (IP) (symbol PTGIR; older synonymous symbol IP).

Template:PBB Summary

Transduction

When binding a prostacyclin-molecule, the receptor changes conformation and activates G_s, with its activation of cAMP and increase in protein kinase A (PKA) activity.

In vasodilation

In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.^[5]

Gene

The receptor is encoded by the human gene PTGIR.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160013 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043017 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Walter F. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 479
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

External links

"Prostanoid Receptors: IP₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.