Prostaglandin DP₁ receptor

PTGDR
Identifiers
Aliases	PTGDR, AS1, ASRT1, DP, DP1, PTGDR1, prostaglandin D2 receptor (DP), prostaglandin D2 receptor
External IDs	OMIM: 604687; MGI: 102966; HomoloGene: 736; GeneCards: PTGDR; OMA:PTGDR - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	52,276,724 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	45,096,832 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; rectum; ; parietal pleura; ; mucosa of sigmoid colon; ; germinal epithelium; ; trigeminal ganglion; ; blood; ; spleen; ; visceral pleura;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; pharynx; ; larynx; ; embryo; ; respiratory epithelium; ; nasal epithelium; ; olfactory epithelium; ; knee joint; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; G protein-coupled receptor activity; prostaglandin J receptor activity; prostaglandin D receptor activity; prostaglandin E receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure;
Biological process	sleep; adenosine metabolic process; signal transduction; male sex determination; inflammatory response; cellular response to prostaglandin E stimulus; cellular response to prostaglandin D stimulus; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	5729
	19214
	ENSG00000168229
	ENSMUSG00000071489
	Q13258
	P70263
	NM_000953; NM_001281469
	NM_008962
	NP_000944; NP_001268398
	NP_032988
	Wikidata
View/Edit Human	View/Edit Mouse

Prostaglandin D₂ receptor 1 (DP₁) is a G protein-coupled receptor, encoded by the PTGDR1 gene, for prostaglandin D₂ (PGD₂).^[5] Template:PBB Summary

Mechanism

DP₁ is a G protein-coupled receptor (GPCR). Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca²⁺.

Function

Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D₂, functions as a mast cell-derived mediator to trigger asthmatic responses.^[5] It also causes vasodilation.

Ligands

Agonists

Prostaglandin D₂ - non-selective
Treprostinil - non-selective

Antagonists ^[6]

Asapiprant (S-555739) - selective
Laropiprant - selective
Vidupiprant - dual DP₁ and DP₂ antagonist

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168229 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071489 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PTGDR prostaglandin D2 receptor (DP)".
^ Norman P (Jan 2014). "Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs". Expert Opin Investig Drugs. 23 (1): 55–66. doi:10.1517/13543784.2013.839658. PMID 24073896.

External links

"Prostanoid Receptors: DP₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.