CCR1

CCR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y5D
Identifiers
Aliases	CCR1, CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C motif chemokine receptor 1
External IDs	OMIM: 601159; MGI: 104618; HomoloGene: 20344; GeneCards: CCR1; OMA:CCR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,208,313 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,768,729 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; periodontal fiber; ; buccal mucosa cell; ; appendix; ; spleen; ; decidua; ; bone marrow; ; trabecular bone;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; tibiofemoral joint; ; blood; ; ankle; ; body of femur; ; spleen; ; ankle joint; ; lumbar subsegment of spinal cord; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-C chemokine binding; G protein-coupled receptor activity; chemokine (C-C motif) ligand 5 binding; signal transducer activity; chemokine (C-C motif) ligand 7 binding; protein binding; chemokine receptor activity; C-C chemokine receptor activity; phosphatidylinositol phospholipase C activity; chemokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane; cytoplasm;
Biological process	negative regulation of bone mineralization; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; chemokine-mediated signaling pathway; cell-cell signaling; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; positive regulation of monocyte chemotaxis; cellular calcium ion homeostasis; positive regulation of osteoclast differentiation; dendritic cell chemotaxis; negative regulation of gene expression; chemotaxis; cell surface receptor signaling pathway; cell adhesion; response to wounding; immune response; positive regulation of ERK1 and ERK2 cascade; inflammatory response; calcium ion transport; signal transduction; exocytosis; positive regulation of calcium ion transport; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1230
	12768
	ENSG00000163823
	ENSMUSG00000025804
	P32246
	P51675
	NM_001295
	NM_009912
	NP_001286
	NP_034042
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.^[5]

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

Function

This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.^[6]

Interactions

CCR1 has been shown to interact with CCL5.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163823 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025804 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (February 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell. 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328.
^ "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".
^ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". European Journal of Immunology. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID 11449371.
^ Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (April 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". The Journal of Biological Chemistry. 276 (14): 10620–6. doi:10.1074/jbc.M010867200. PMID 11116158.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology. 12 (1): 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (January 2004). "HIV-1 infection and chemokine receptor modulation". Current HIV Research. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339.
Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609.
Ben-Baruch A, Xu L, Young PR, Bengali K, Oppenheim JJ, Wang JM (September 1995). "Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3". The Journal of Biological Chemistry. 270 (38): 22123–8. doi:10.1074/jbc.270.38.22123. PMID 7545673.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C (December 1995). "Molecular characterization of two murine eosinophil beta chemokine receptors". Journal of Immunology. 155 (11): 5299–305. PMID 7594543.
Gao JL, Kuhns DB, Tiffany HL, McDermott D, Li X, Francke U, Murphy PM (May 1993). "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor". The Journal of Experimental Medicine. 177 (5): 1421–7. doi:10.1084/jem.177.5.1421. PMC 2191019. PMID 7683036.
Combadiere C, Ahuja SK, Van Damme J, Tiffany HL, Gao JL, Murphy PM (December 1995). "Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B". The Journal of Biological Chemistry. 270 (50): 29671–5. doi:10.1074/jbc.270.50.29671. PMID 8530354.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kuang Y, Wu Y, Jiang H, Wu D (February 1996). "Selective G protein coupling by C-C chemokine receptors". The Journal of Biological Chemistry. 271 (8): 3975–8. doi:10.1074/jbc.271.8.3975. PMID 8626727.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Boring L, Gosling J, Monteclaro FS, Lusis AJ, Tsou CL, Charo IF (March 1996). "Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9". The Journal of Biological Chemistry. 271 (13): 7551–8. doi:10.1074/jbc.271.13.7551. PMID 8631787.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Gong X, Gong W, Kuhns DB, Ben-Baruch A, Howard OM, Wang JM (May 1997). "Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors". The Journal of Biological Chemistry. 272 (18): 11682–5. doi:10.1074/jbc.272.18.11682. PMID 9115216.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Daugherty BL, Springer MS (April 1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21". Genomics. 41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID 9143512.
Pakianathan DR, Kuta EG, Artis DR, Skelton NJ, Hébert CA (August 1997). "Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5". Biochemistry. 36 (32): 9642–8. doi:10.1021/bi970593z. PMID 9289016.
Coulin F, Power CA, Alouani S, Peitsch MC, Schroeder JM, Moshizuki M, Clark-Lewis I, Wells TN (September 1997). "Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines". European Journal of Biochemistry / FEBS. 248 (2): 507–15. doi:10.1111/j.1432-1033.1997.00507.x. PMID 9346309.
Youn BS, Zhang SM, Broxmeyer HE, Cooper S, Antol K, Fraser M, Kwon BS (May 1998). "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1". Blood. 91 (9): 3118–26. PMID 9558365.
Nardelli B, Tiffany HL, Bong GW, Yourey PA, Morahan DK, Li Y, Murphy PM, Alderson RF (January 1999). "Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1". Journal of Immunology. 162 (1): 435–44. PMID 9886417.
Shaw KT, Greig NH (January 1999). "Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection". Neuroreport. 10 (1): 53–6. doi:10.1097/00001756-199901180-00010. PMID 10094132.
Zhang S, Youn BS, Gao JL, Murphy PM, Kwon BS (April 1999). "Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1". Journal of Immunology. 162 (8): 4938–42. PMID 10202040.
Lalani AS, Masters J, Zeng W, Barrett J, Pannu R, Everett H, Arendt CW, McFadden G (December 1999). "Use of chemokine receptors by poxviruses". Science. 286 (5446): 1968–71. doi:10.1126/science.286.5446.1968. PMID 10583963.

External links

"Chemokine Receptors: CCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163823 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025804 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7679328-5] Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (February 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell. 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328.

[6] "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".

[pmid11449371-7] Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". European Journal of Immunology. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID 11449371.

[pmid11116158-8] Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (April 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". The Journal of Biological Chemistry. 276 (14): 10620–6. doi:10.1074/jbc.M010867200. PMID 11116158.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Function

Interactions

References

Further reading

External links