Interleukin 1 receptor, type II

Interleukin 1 receptor, type II
Available structures PDB 3O4O
Identifiers
Symbols	IL1R2; CD121b; IL1RB
External IDs	OMIM: 147811 MGI: 96546 HomoloGene: 7783 GeneCards: IL1R2 Gene
Gene Ontology Molecular function • receptor activity • interleukin-1 receptor activity • interleukin-1, Type II, blocking receptor activity • protein binding Cellular component • extracellular region • plasma membrane • integral to membrane Biological process • immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7850	16178
Ensembl	ENSG00000115590	ENSMUSG00000026073
UniProt	P27930	P27931
RefSeq (mRNA)	NM_004633.3	NM_010555.4
RefSeq (protein)	NP_004624.1	NP_034685.1
Location (UCSC)	Chr 2: 102.61 – 102.65 Mb	Chr 1: 40.14 – 40.18 Mb
PubMed search	[1]	[2]

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.

See also

• Cluster of differentiation
• Interleukin 1 receptor, type I

Further reading

• McMahan CJ, Slack JL, Mosley B et al (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. PMC 452992. PMID 1833184. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452992. 
• Dripps DJ, Verderber E, Ng RK et al (1991). "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils". J. Biol. Chem. 266 (30): 20311–5. PMID 1834644. 
• Fasano MB, Cousart S, Neal S, McCall CE (1991). "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome". J. Clin. Invest. 88 (5): 1452–9. doi:10.1172/JCI115454. PMC 295647. PMID 1834697. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=295647. 
• Sadouk MB, Pelletier JP, Tardif G et al (1995). "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor". Lab. Invest. 73 (3): 347–55. PMID 7564267. 
• Symons JA, Young PR, Duff GW (1995). "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1714–8. doi:10.1073/pnas.92.5.1714. PMC 42590. PMID 7878046. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42590. 
• Arend WP, Malyak M, Smith MF et al (1994). "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids". J. Immunol. 153 (10): 4766–74. PMID 7963543. 
• Giri JG, Wells J, Dower SK et al (1995). "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses". J. Immunol. 153 (12): 5802–9. PMID 7989776. 
• Re F, Muzio M, De Rossi M et al (1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor". J. Exp. Med. 179 (2): 739–43. doi:10.1084/jem.179.2.739. PMC 2191363. PMID 8294881. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2191363. 
• Colotta F, Re F, Muzio M et al (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science 261 (5120): 472–5. doi:10.1126/science.8332913. PMID 8332913. 
• Sambo P, Fadlon EJ, Sironi M et al (1996). "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells". Blood 87 (5): 1682–6. PMID 8634411. 
• Larregina A, Morelli A, Kolkowski E, Fainboim L (1996). "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture". Immunology 87 (2): 317–25. doi:10.1046/j.1365-2567.1996.451513.x. PMC 1384291. PMID 8698397. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1384291. 
• Liu C, Hart RP, Liu XJ et al (1996). "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". J. Biol. Chem. 271 (34): 20965–72. doi:10.1074/jbc.271.34.20965. PMID 8702856. 
• Colotta F, Saccani S, Giri JG et al (1996). "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes". J. Immunol. 156 (7): 2534–41. PMID 8786316. 
• Sébire G, Delfraissy JF, Demotes-Mainard J et al (1997). "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine 8 (8): 636–41. doi:10.1006/cyto.1996.0085. PMID 8894439. 
• Lovenberg TW, Crowe PD, Liu C et al (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J. Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. 
• van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF (1997). "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13". J. Infect. Dis. 175 (1): 118–22. doi:10.1093/infdis/175.1.118. PMID 8985204. 
• Rauschmayr T, Groves RW, Kupper TS (1997). "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5814–9. doi:10.1073/pnas.94.11.5814. PMC 20863. PMID 9159157. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20863. 
• Gomez E, Morel G, Cavalier A et al (1997). "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biol. Reprod. 56 (6): 1513–26. doi:10.1095/biolreprod56.6.1513. PMID 9166705. 
• Cannon JG, Angel JB, Abad LW et al (1997). "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". J. Clin. Immunol. 17 (3): 253–61. doi:10.1023/A:1027314713231. PMID 9168406. 
• Fink GW, Norman JG (1998). "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis". Cytokine 9 (12): 1023–7. doi:10.1006/cyto.1997.0260. PMID 9417814. 

External links

• MeSH IL1R2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.