Fibroblast growth factor receptor 4

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Fibroblast growth factor receptor 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FGFR4 ; CD334; JTK2; TKF
External IDs OMIM134935 MGI95525 HomoloGene20461 ChEMBL: 3973 GeneCards: FGFR4 Gene
EC number
RNA expression pattern
PBB GE FGFR4 204579 at tn.png
PBB GE FGFR4 211237 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2264 14186
Ensembl ENSG00000160867 ENSMUSG00000005320
UniProt P22455 Q03142
RefSeq (mRNA) NM_001291980 NM_008011
RefSeq (protein) NP_001278909 NP_032037
Location (UCSC) Chr 5:
177.09 – 177.1 Mb
Chr 13:
55.15 – 55.17 Mb
PubMed search [1] [2]

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334).

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.[1]


Fibroblast growth factor receptor 4 has been shown to interact with FGF1.[2][3]


  1. ^ "Entrez Gene: FGFR4 fibroblast growth factor receptor 4". 
  2. ^ Loo, B B; Darwish K K; Vainikka S S; Saarikettu J J; Vihko P P; Hermonen J J; Goldman A A; Alitalo K K; Jalkanen M M (May 2000). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". Int. J. Biochem. Cell Biol. (ENGLAND) 32 (5): 489–97. doi:10.1016/S1357-2725(99)00145-4. ISSN 1357-2725. PMID 10736564. 
  3. ^ Kan, M; Wu X; Wang F; McKeehan W L (May 1999). "Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase". J. Biol. Chem. (UNITED STATES) 274 (22): 15947–52. doi:10.1074/jbc.274.22.15947. ISSN 0021-9258. PMID 10336501. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.