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Adhesion G protein-coupled receptor L1
Symbols ADGRL1 ; CIRL1; CL1; LEC2; LPHN1
External IDs OMIM616416 MGI1929461 HomoloGene8951 IUPHAR: GeneCards: ADGRL1 Gene
RNA expression pattern
PBB GE LPHN1 203488 at tn.png
PBB GE LPHN1 219145 at tn.png
PBB GE LPHN1 47560 at tn.png
More reference expression data
Species Human Mouse
Entrez 22859 330814
Ensembl ENSG00000072071 ENSMUSG00000013033
UniProt O94910 Q80TR1
RefSeq (mRNA) NM_001008701 NM_181039
RefSeq (protein) NP_001008701 NP_851382
Location (UCSC) Chr 19:
14.15 – 14.21 Mb
Chr 8:
83.9 – 83.94 Mb
PubMed search [1] [2]

Latrophilin-1 is a protein that in humans is encoded by the ADGRL1 gene.[1][2] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4][5]


This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane.[2]

See also[edit]


  1. ^ Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". J Recept Signal Transduct Res 20 (2–3): 119–31. doi:10.3109/10799890009150640. PMID 10994649. 
  2. ^ a b "Entrez Gene: LPHN1 latrophilin 1". 
  3. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  5. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.