IRX4: Difference between revisions

IRX4
Identifiers
Aliases	IRX4, IRXA3, iroquois homeobox 4
External IDs	OMIM: 606199 MGI: 1355275 HomoloGene: 9485 GeneCards: IRX4
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,887,236 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,417,727 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; hair follicle; ; left ventricle; ; minor salivary glands; ; vagina; ; right ventricle; ; nipple; ; prostate; ; lactiferous duct; ; gums;
	Top expressed in
	lip; ; ventricle; ; atrioventricular canal; ; endocardial cushion; ; myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; atrioventricular valve; ; upper lip; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	heart development; regulation of transcription, DNA-templated; establishment of animal organ orientation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	50805
	50916
	ENSG00000113430
	ENSMUSG00000021604
	P78413
	Q9QY61
	NM_016358; NM_001278632; NM_001278633; NM_001278634; NM_001278635
	NM_018885
	NP_001265561; NP_001265562; NP_001265563; NP_001265564; NP_057442
	NP_061373
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 00:36, 3 September 2021

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.^[5]^[6]

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: iroquois homeobox 4".
^ Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.

Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142. S2CID 37046813.
Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). "Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression". J. Biol. Chem. 276 (31): 28835–41. doi:10.1074/jbc.M103716200. PMID 11382777.
Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy". Turk Kardiyol Dern Ars. 36 (2): 90–5. PMID 18497553.
Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): 815–820. doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: iroquois homeobox 4".

[pmid10625552-6] Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.

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 ==Further reading==
 {{refbegin | 2}}
-*{{cite journal   |vauthors=Lewis MT, Ross S, Strickland PA, etal |title=Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. |journal=Cell Tissue Res. |volume=296 |issue= 3 |pages= 549–54 |year= 1999 |pmid= 10370142 |doi=  10.1007/s004410051316|s2cid=37046813 }}
+*{{cite journal   |vauthors=Lewis MT, Ross S, Strickland PA, etal |title=Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. |journal=Cell Tissue Res. |volume=296 |issue= 3 |pages= 549–54 |year= 1999 |pmid= 10370142 |doi=  10.1007/s004410051316|s2cid=37046813 |url=https://escholarship.org/uc/item/6q61x39v }}
 *{{cite journal  |vauthors=Wang GF, Nikovits W, Bao ZZ, Stockdale FE |title=Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28835–41 |year= 2001 |pmid= 11382777 |doi= 10.1074/jbc.M103716200 |doi-access= free }}
 *{{cite journal   |vauthors=Bayrak F, Kömürcü-Bayrak E, Mutlu B, etal |title=Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy. |journal=Turk Kardiyol Dern Ars |volume=36 |issue= 2 |pages= 90–5 |year= 2008 |pmid= 18497553 }}
 *{{cite journal   |vauthors=Cirulli ET, Kasperavičiūtė D, Attix DK, etal |title=Common genetic variation and performance on standardized cognitive tests. |journal=European Journal of Human Genetics |volume= 18|issue=  7|pages= 815–820 |year= 2010 |pmid= 20125193 |doi= 10.1038/ejhg.2010.2 |pmc=2987367}}
-*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }}
 {{refend}}