MEIS1

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Meis homeobox 1
Identifiers
Symbols MEIS1 ; MGC43380
External IDs OMIM601739 MGI104717 HomoloGene135741 GeneCards: MEIS1 Gene
RNA expression pattern
PBB GE MEIS1 204069 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4211 17268
Ensembl ENSG00000143995 ENSMUSG00000020160
UniProt O00470 Q60954
RefSeq (mRNA) NM_002398 NM_001193271
RefSeq (protein) NP_002389 NP_001180200
Location (UCSC) Chr 2:
66.66 – 66.8 Mb
Chr 11:
18.88 – 19.02 Mb
PubMed search [1] [2]

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.[1][2]

Function[edit]

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[2]

Interactions[edit]

MEIS1 has been shown to interact with PBX1[3][4][5] and HOXA9.[3][6]

References[edit]

  1. ^ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology 15 (10): 5434–43. PMC 230793. PMID 7565694. 
  2. ^ a b "Entrez Gene: MEIS1 Meis homeobox 1". 
  3. ^ a b Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. PMC 84099. PMID 10082572. 
  4. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. PMC 84774. PMID 10523646. 
  5. ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology 19 (7): 5134–42. PMC 84356. PMID 10373562. 
  6. ^ Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM et al. (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology 17 (11): 6448–58. PMC 232497. PMID 9343407. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.