HOXA5

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Homeobox A5
Protein HOXA5 PDB 1hom.png
PDB rendering based on 1hom.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HOXA5 ; HOX1; HOX1.3; HOX1C
External IDs OMIM142952 MGI96177 HomoloGene40726 GeneCards: HOXA5 Gene
RNA expression pattern
PBB GE HOXA5 213844 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3202 15402
Ensembl ENSG00000106004 ENSMUSG00000038253
UniProt P20719 P09021
RefSeq (mRNA) NM_019102 NM_010453
RefSeq (protein) NP_061975 NP_034583
Location (UCSC) Chr 7:
27.18 – 27.18 Mb
Chr 6:
52.2 – 52.2 Mb
PubMed search [1] [2]

Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.[3]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXA5 homeobox A5". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.