HOXB3

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Homeobox B3
Identifiers
Symbols HOXB3 ; HOX2; HOX2G; Hox-2.7
External IDs OMIM142966 MGI96184 HomoloGene1617 GeneCards: HOXB3 Gene
RNA expression pattern
PBB GE HOXB3 208414 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3213 15410
Ensembl ENSG00000120093 ENSMUSG00000048763
UniProt P14651 P09026
RefSeq (mRNA) NM_002146 NM_001079869
RefSeq (protein) NP_002137 NP_001073338
Location (UCSC) Chr 17:
46.63 – 46.68 Mb
Chr 11:
96.32 – 96.35 Mb
PubMed search [1] [2]

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).[3]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB3 homeobox B3". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.