ING4

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Inhibitor of growth family, member 4
Protein ING4 PDB 1wen.png
PDB rendering based on 1wen.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ING4 ; my036; p29ING4
External IDs OMIM608524 MGI107307 HomoloGene22952 GeneCards: ING4 Gene
RNA expression pattern
PBB GE ING4 48825 at tn.png
PBB GE ING4 218234 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51147 28019
Ensembl ENSG00000111653 ENSMUSG00000030330
UniProt Q9UNL4 Q8C0D7
RefSeq (mRNA) NM_001127582 NM_133345
RefSeq (protein) NP_001121054 NP_579923
Location (UCSC) Chr 12:
6.76 – 6.77 Mb
Chr 6:
125.04 – 125.05 Mb
PubMed search [1] [2]

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.[1][2]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.[2]

Interactions[edit]

ING4 has been shown to interact with EP300,[1] RELA[3] and P53.[1][4]

References[edit]

  1. ^ a b c Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res 63 (10): 2373–8. PMID 12750254. 
  2. ^ a b "Entrez Gene: ING4 inhibitor of growth family, member 4". 
  3. ^ Garkavtsev, Igor; Kozin Sergey V; Chernova Olga; Xu Lei; Winkler Frank; Brown Edward; Barnett Gene H; Jain Rakesh K (Mar 2004). "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis". Nature (England) 428 (6980): 328–32. doi:10.1038/nature02329. PMID 15029197. 
  4. ^ Tsai, Kuo-Wang; Tseng Hsiao-Chun; Lin Wen-Chang (Oct 2008). "Two wobble-splicing events affect ING4 protein subnuclear localization and degradation". Exp. Cell Res. (United States) 314 (17): 3130–41. doi:10.1016/j.yexcr.2008.08.002. PMID 18775696. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.