MAFF (gene)

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V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
Identifiers
Symbols MAFF ; U-MAF; hMafF
External IDs OMIM604877 MGI96910 HomoloGene7825 GeneCards: MAFF Gene
RNA expression pattern
PBB GE MAFF 36711 at tn.png
PBB GE MAFF 205193 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23764 17133
Ensembl ENSG00000185022 ENSMUSG00000042622
UniProt Q9ULX9 O54791
RefSeq (mRNA) NM_001161572 NM_010755
RefSeq (protein) NP_001155044 NP_034885
Location (UCSC) Chr 22:
38.6 – 38.61 Mb
Chr 15:
79.35 – 79.36 Mb
PubMed search [1] [2]

Transcription factor MafF is a protein that in humans is encoded by the MAFF gene.[1][2]

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Two transcript variants encoding the same protein have been found for this gene.[2]

See also[edit]

References[edit]

  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ a b "Entrez Gene: MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.