PHF21A

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PHD finger protein 21A
Protein PHF21A PDB 2PUY.png
Rendering based on PDB 2PUY.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PHF21A ; BHC80
External IDs OMIM608325 HomoloGene9597 GeneCards: PHF21A Gene
RNA expression pattern
PBB GE PHF21A 203278 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51317 192285
Ensembl ENSG00000135365 ENSMUSG00000058318
UniProt Q96BD5 Q6ZPK0
RefSeq (mRNA) NM_001101802 NM_001109690
RefSeq (protein) NP_001095272 NP_001103160
Location (UCSC) Chr 11:
45.95 – 46.14 Mb
Chr 2:
92.09 – 92.36 Mb
PubMed search [1] [2]

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.[1][2][3]

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM][3]

Interactions[edit]

PHF21A has been shown to interact with HMG20B,[2][4] HDAC1,[2][4] Histone deacetylase 2[2][4][5] and RCOR1.[2][4]

References[edit]

  1. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  2. ^ a b c d e Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core–BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc Natl Acad Sci U S A 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298. 
  3. ^ a b "Entrez Gene: PHF21A PHD finger protein 21A". 
  4. ^ a b c d Iwase, Shigeki; Januma Aya, Miyamoto Kiyoko, Shono Naomi, Honda Arata, Yanagisawa Junn, Baba Tadashi (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. (United States) 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. ISSN 0006-291X. PMID 15325272. 
  5. ^ Hakimi, Mohamed-Ali; Dong Yuanshu, Lane William S, Speicher David W, Shiekhattar Ramin (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. (United States) 278 (9): 7234–9. doi:10.1074/jbc.M208992200. ISSN 0021-9258. PMID 12493763. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.