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PHD finger protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PHF1 ; MTF2L2; PCL1; PHF2; TDRD19C; hPHF1
External IDs OMIM602881 MGI98647 HomoloGene7567 GeneCards: PHF1 Gene
RNA expression pattern
PBB GE PHF1 40446 at tn.png
PBB GE PHF1 202928 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5252 21652
Ensembl ENSG00000112511 ENSMUSG00000024193
UniProt O43189 Q9Z1B8
RefSeq (mRNA) NM_002636 NM_009343
RefSeq (protein) NP_002627 NP_033369
Location (UCSC) Chr 6:
33.38 – 33.38 Mb
Chr 17:
26.93 – 26.94 Mb
PubMed search [1] [2]

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.[1][2][3]

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.[3]


  1. ^ Coulson M, Robert S, Eyre HJ, Saint R (Jun 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics 48 (3): 381–3. doi:10.1006/geno.1997.5201. PMID 9545646. 
  2. ^ Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Res 36 (9): 2939–47. doi:10.1093/nar/gkn146. PMC 2396414. PMID 18385154. 
  3. ^ a b "Entrez Gene: PHF1 PHD finger protein 1". 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.