ELK4

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ELK4, ETS-domain protein (SRF accessory protein 1)
Protein ELK4 PDB 1bc7.png
PDB rendering based on 1bc7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ELK4 ; SAP1
External IDs OMIM600246 MGI102853 HomoloGene1492 GeneCards: ELK4 Gene
RNA expression pattern
PBB GE ELK4 206919 at tn.png
PBB GE ELK4 205994 at tn.png
PBB GE ELK4 214831 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2005 13714
Ensembl ENSG00000158711 ENSMUSG00000026436
UniProt P28324 P41158
RefSeq (mRNA) NM_001973 NM_007923
RefSeq (protein) NP_001964 NP_031949
Location (UCSC) Chr 1:
205.58 – 205.6 Mb
Chr 1:
132.01 – 132.03 Mb
PubMed search [1] [2]

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.[1][2][3]

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[3]

Interactions[edit]

ELK4 has been shown to interact with Serum response factor[4][5] and BRCA1.[6]

References[edit]

  1. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904. 
  2. ^ Giovane A, Sobieszczuk P, Mignon C, Mattei MG, Wasylyk B (Mar 1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes". Genomics 29 (3): 769–72. doi:10.1006/geno.1995.9938. PMID 8575773. 
  3. ^ a b "Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)". 
  4. ^ Hassler, M; Richmond T J (Jun 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. (England) 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. ISSN 0261-4189. PMC 150215. PMID 11406578. 
  5. ^ Zhu, C; Johansen F E; Prywes R (Sep 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. (UNITED STATES) 17 (9): 4957–66. ISSN 0270-7306. PMC 232347. PMID 9271374. 
  6. ^ Chai, Y; Chipitsyna G; Cui J; Liao B; Liu S; Aysola K; Yezdani M; Reddy E S; Rao V N (Mar 2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene (England) 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. ISSN 0950-9232. PMID 11313879. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.