HOXD10

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Homeobox D10
Identifiers
Symbols HOXD10 ; HOX4; HOX4D; HOX4E; Hox-4.4
External IDs OMIM142984 MGI96202 HomoloGene1619 GeneCards: HOXD10 Gene
RNA expression pattern
PBB GE HOXD10 207373 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3236 15430
Ensembl ENSG00000128710 ENSMUSG00000050368
UniProt P28358 P28359
RefSeq (mRNA) NM_002148 NM_013554
RefSeq (protein) NP_002139 NP_038582
Location (UCSC) Chr 2:
176.97 – 176.98 Mb
Chr 2:
74.69 – 74.7 Mb
PubMed search [1] [2]

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.[1]

Function[edit]

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance[edit]

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.[1][citation needed]

Regulation[edit]

The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.[2][3][4]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: HOXD10 homeobox D10". 
  2. ^ Lund AH (2010). "miR-10 in development and cancer.". Cell Death Differ 17 (2): 209–14. doi:10.1038/cdd.2009.58. PMID 19461655. 
  3. ^ Ma L, Teruya-Feldstein J, Weinberg RA (2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.". Nature 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713. 
  4. ^ Han L, Witmer PD, Casey E, Valle D, Sukumar S (2007). "DNA methylation regulates MicroRNA expression.". Cancer Biol Ther 6 (8): 1284–8. PMID 17660710. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.