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Single-minded family bHLH transcription factor 2
Symbols SIM2 ; HMC13F06; HMC29C01; SIM; bHLHe15
External IDs OMIM600892 MGI98307 HomoloGene3716 GeneCards: SIM2 Gene
RNA expression pattern
PBB GE SIM2 206558 at tn.png
More reference expression data
Species Human Mouse
Entrez 6493 20465
Ensembl ENSG00000159263 ENSMUSG00000062713
UniProt Q14190 Q61079
RefSeq (mRNA) NM_005069 NM_011377
RefSeq (protein) NP_005060 NP_035507
Location (UCSC) Chr 21:
38.07 – 38.12 Mb
Chr 16:
94.09 – 94.13 Mb
PubMed search [1] [2]

Single-minded homolog 2 is a protein that in humans is encoded by the SIM2 gene.[1][2]


SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of neurogenesis of midline cells in the central nervous system. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes[2]


SIM2 has been shown to interact with Aryl hydrocarbon receptor nuclear translocator.[3][4][5][6]


  1. ^ Muenke M, Bone LJ, Mitchell HF, Hart I, Walton K, Hall-Johnson K, Ippel EF, Dietz-Band J, Kvaloy K, Fan CM et al. (November 1995). "Physical Mapping of the Holoprosencephaly Critical Region in 21q22.3, Exclusion of SIM2 as a Candidate Gene for Holoprosencephaly, and Mapping of SIM2 to a Region of Chromosome 21 Important for Down Syndrome". Am J Hum Genet 57 (5): 1074–9. PMC 1801356. PMID 7485157. 
  2. ^ a b "Entrez Gene: SIM2 single-minded homolog 2 (Drosophila)". 
  3. ^ Probst, M R; Fan C M; Tessier-Lavigne M; Hankinson O (February 1997). "Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein". J. Biol. Chem. (UNITED STATES) 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. ISSN 0021-9258. PMID 9020169. 
  4. ^ Ooe, Norihisa; Saito Koichi; Mikami Nobuyoshi; Nakatuka Iwao; Kaneko Hideo (January 2004). "Identification of a Novel Basic Helix-Loop-Helix-PAS Factor, NXF, Reveals a Sim2 Competitive, Positive Regulatory Role in Dendritic-Cytoskeleton Modulator Drebrin Gene Expression". Mol. Cell. Biol. (United States) 24 (2): 608–16. doi:10.1128/MCB.24.2.608-616.2004. ISSN 0270-7306. PMC 343817. PMID 14701734. 
  5. ^ Woods, Susan L; Whitelaw Murray L (March 2002). "Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". J. Biol. Chem. (United States) 277 (12): 10236–43. doi:10.1074/jbc.M110752200. ISSN 0021-9258. PMID 11782478. 
  6. ^ Moffett, P; Reece M; Pelletier J (September 1997). "The murine Sim-2 gene product inhibits transcription by active repression and functional interference". Mol. Cell. Biol. (UNITED STATES) 17 (9): 4933–47. ISSN 0270-7306. PMC 232345. PMID 9271372. 

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