POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2gene.
N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM]
^Waragai, M; Lammers C H, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian M M, Okazawa H (Jun 1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival". Hum. Mol. Genet. (ENGLAND) 8 (6): 977–87. doi:10.1093/hmg/8.6.977. ISSN0964-6906. PMID10332029.Cite uses deprecated parameters (help)
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