POU3F2

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POU class 3 homeobox 2
Identifiers
Symbols POU3F2 ; BRN2; N-Oct3; OCT7; OTF-7; OTF7; POUF3; brn-2; oct-7
External IDs OMIM600494 MGI101895 HomoloGene4095 ChEMBL: 4189 GeneCards: POU3F2 Gene
RNA expression pattern
PBB GE POU3F2 207084 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5454 18992
Ensembl ENSG00000184486 ENSMUSG00000095139
UniProt P20265 P31360
RefSeq (mRNA) NM_005604 NM_008899
RefSeq (protein) NP_005595 NP_032925
Location (UCSC) Chr 6:
99.28 – 99.29 Mb
Chr 4:
22.48 – 22.49 Mb
PubMed search [1] [2]

POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.[1][2]

N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM][2]

Interactions[edit]

POU3F2 has been shown to interact with PQBP1.[3]

See also[edit]

References[edit]

  1. ^ Schreiber E, Tobler A, Malipiero U, Schaffner W, Fontana A (Mar 1993). "cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif". Nucleic Acids Res 21 (2): 253–8. doi:10.1093/nar/21.2.253. PMC 309100. PMID 8441633. 
  2. ^ a b "Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2". 
  3. ^ Waragai, M; Lammers C H, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian M M, Okazawa H (Jun 1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival". Hum. Mol. Genet. (ENGLAND) 8 (6): 977–87. doi:10.1093/hmg/8.6.977. ISSN 0964-6906. PMID 10332029. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.