HOPX

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HOP homeobox
Protein HOP PDB 2hi3.png
PDB rendering based on 2hi3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HOPX ; CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31; TOTO
External IDs OMIM607275 MGI1916782 HomoloGene15859 GeneCards: HOPX Gene
RNA expression pattern
PBB GE HOP 211597 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 84525 74318
Ensembl ENSG00000171476 ENSMUSG00000059325
UniProt Q9BPY8 Q8R1H0
RefSeq (mRNA) NM_001145459 NM_001159900
RefSeq (protein) NP_001138931 NP_001153372
Location (UCSC) Chr 4:
57.51 – 57.55 Mb
Chr 5:
77.09 – 77.12 Mb
PubMed search [1] [2]

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene.[1][2]

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[2]

References[edit]

  1. ^ Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA (Sep 2002). "Hop is an unusual homeobox gene that modulates cardiac development". Cell 110 (6): 713–23. doi:10.1016/S0092-8674(02)00932-7. PMID 12297045. 
  2. ^ a b "Entrez Gene: HOP homeodomain-only protein". 

Further reading[edit]

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.