MXD1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
MAX dimerization protein 1
Protein MXD1 PDB 1nlw.png
PDB rendering based on 1nlw.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MXD1 ; BHLHC58; MAD; MAD1
External IDs OMIM600021 MGI96908 HomoloGene1767 GeneCards: MXD1 Gene
RNA expression pattern
PBB GE MXD1 206877 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4084 17119
Ensembl ENSG00000059728 ENSMUSG00000001156
UniProt Q05195 Q8K1Z8
RefSeq (mRNA) NM_001202513 NM_010751
RefSeq (protein) NP_001189442 NP_034881
Location (UCSC) Chr 2:
69.9 – 69.94 Mb
Chr 6:
86.65 – 86.67 Mb
PubMed search [1] [2]

MAD protein is a protein that in humans is encoded by the MXD1 gene.[1][2]

MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.[2] The MAD-MAX protein dimer may be a reference to the popular cult classic film Mad Max (1979).

Interactions[edit]

MXD1 has been shown to interact with Histone deacetylase 2,[3][4] SMC3,[5] MLX,[6][7] SIN3A[8][9][10] and MAX.[5][11][12][13]

References[edit]

  1. ^ Shapiro DN, Valentine V, Eagle L, Yin X, Morris SW, Prochownik EV (February 1995). "Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25". Genomics 23 (1): 282–5. doi:10.1006/geno.1994.1496. PMID 7829091. 
  2. ^ a b "Entrez Gene: MXD1 MAX dimerization protein 1". 
  3. ^ Laherty, C D; Yang W M; Sun J M; Davie J R; Seto E; Eisenman R N (May 1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell (UNITED STATES) 89 (3): 349–56. doi:10.1016/S0092-8674(00)80215-9. ISSN 0092-8674. PMID 9150134. 
  4. ^ Spronk, C A; Tessari M; Kaan A M; Jansen J F; Vermeulen M; Stunnenberg H G; Vuister G W (December 2000). "The Mad1-Sin3B interaction involves a novel helical fold". Nat. Struct. Biol. (UNITED STATES) 7 (12): 1100–4. doi:10.1038/81944. ISSN 1072-8368. PMID 11101889. 
  5. ^ a b Gupta, K; Anand G; Yin X; Grove L; Prochownik E V (March 1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene (ENGLAND) 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. ISSN 0950-9232. PMID 9528857. 
  6. ^ Cairo, S; Merla G; Urbinati F; Ballabio A; Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. (England) 10 (6): 617–27. doi:10.1093/hmg/10.6.617. ISSN 0964-6906. PMID 11230181. 
  7. ^ Meroni, G; Cairo S; Merla G; Messali S; Brent R; Ballabio A; Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene (ENGLAND) 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583. 
  8. ^ Swanson, Kurt A; Knoepfler Paul S; Huang Kai; Kang Richard S; Cowley Shaun M; Laherty Carol D; Eisenman Robert N; Radhakrishnan Ishwar (August 2004). "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations". Nat. Struct. Mol. Biol. (United States) 11 (8): 738–46. doi:10.1038/nsmb798. ISSN 1545-9993. PMID 15235594. 
  9. ^ Brubaker, K; Cowley S M; Huang K; Loo L; Yochum G S; Ayer D E; Eisenman R N; Radhakrishnan I (November 2000). "Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex". Cell (UNITED STATES) 103 (4): 655–65. doi:10.1016/S0092-8674(00)00168-9. ISSN 0092-8674. PMID 11106735. 
  10. ^ Ayer, D E; Lawrence Q A; Eisenman R N (March 1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3". Cell (UNITED STATES) 80 (5): 767–76. doi:10.1016/0092-8674(95)90355-0. ISSN 0092-8674. PMID 7889570. 
  11. ^ Lee, Clement M; Onésime Djamila; Reddy C Damodara; Dhanasekaran N; Reddy E Premkumar (October 2002). "JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (22): 14189–94. doi:10.1073/pnas.232310199. ISSN 0027-8424. PMC 137859. PMID 12391307. 
  12. ^ Ayer, D E; Kretzner L; Eisenman R N (January 1993). "Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity". Cell (UNITED STATES) 72 (2): 211–22. doi:10.1016/0092-8674(93)90661-9. ISSN 0092-8674. PMID 8425218. 
  13. ^ Nair, Satish K; Burley Stephen K (January 2003). "X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors". Cell (United States) 112 (2): 193–205. doi:10.1016/S0092-8674(02)01284-9. ISSN 0092-8674. PMID 12553908. 

Further reading[edit]