This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family has at least six members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7.
Crackower MA, Scherer SW, Rommens JM, et al. (1997). "Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development.". Hum. Mol. Genet.5 (5): 571–9. doi:10.1093/hmg/5.5.571. PMID8733122.
Nabi R, Zhong H, Serajee FJ, Huq AH (2004). "No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism.". Am. J. Med. Genet. B Neuropsychiatr. Genet.119 (1): 98–101. doi:10.1002/ajmg.b.10012. PMID12707945.