HOXB4

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Homeobox B4
Identifiers
Symbols HOXB4 ; HOX-2.6; HOX2; HOX2F
External IDs OMIM142965 MGI96185 HomoloGene32095 GeneCards: HOXB4 Gene
Orthologs
Species Human Mouse
Entrez 3214 15412
Ensembl ENSG00000182742 ENSMUSG00000038692
UniProt P17483 P10284
RefSeq (mRNA) NM_024015 NM_010459
RefSeq (protein) NP_076920 NP_034589
Location (UCSC) Chr 17:
46.65 – 46.66 Mb
Chr 11:
96.32 – 96.32 Mb
PubMed search [1] [2]

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.[3]

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References[edit]

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB4 homeobox B4". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.