Y box binding protein 1

Y box binding protein 1
	; PDB rendering based on 1h95.
Available structures
PDB	1h95
Identifiers
Symbols	YBX1; BP-8; CSDA2; CSDB; DBPB; MDR-NF1; MGC104858; MGC110976; MGC117250; NSEP-1; NSEP1; YB-1; YB1
External IDs	OMIM: 154030 HomoloGene: 88707 GeneCards: YBX1 Gene
Gene Ontology
Molecular function	• DNA binding; • DNA binding; • double-stranded DNA binding; • single-stranded DNA binding; • sequence-specific DNA binding transcription factor activity; • RNA binding; • protein binding;
Cellular component	• extracellular region; • nucleus; • nucleoplasm; • U12-type spliceosomal complex; • cytoplasm; • stress granule; • ribonucleoprotein complex; • CRD-mediated mRNA stability complex; • histone pre-mRNA 3'end processing complex;
Biological process	• nuclear mRNA splicing, via spliceosome; • in utero embryonic development; • regulation of transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • transcription from RNA polymerase II promoter; • RNA splicing; • gene expression; • negative regulation of transcription, DNA-dependent; • positive regulation of cell division; • CRD-mediated mRNA stabilization;
	Sources: Amigo / QuickGO
Orthologs

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Y box binding protein 1, officially known as YBX1, but commonly referred to as "YB-1" by researchers, is a human protein.^[1] Current research is examining its involvement in cancer, and particularly in the metastasis of cancerous cells or prevention thereof.

[edit] Interactions

Y box binding protein 1 has been shown to interact with RBBP6,^[2] PCNA,^[3] ANKRD2,^[4] SFRS9,^[5] CTCF^[6] and P53.^[4]^[7]

[edit] References

^ "Entrez Gene: YBX1 Y box binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4904.
^ Chibi, Moredreck; Meyer Mervin, Skepu Amanda, G Rees D Jasper, Moolman-Smook Johanna C, Pugh David J R (Dec. 2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. (England) 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979.
^ Ise, T; Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (Jan. 1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. (UNITED STATES) 59 (2): 342–6. ISSN 0008-5472. PMID 9927044.
^ ^a ^b Kojic, Snezana; Medeot Elisa, Guccione Ernesto, Krmac Helena, Zara Ivano, Martinelli Valentina, Valle Giorgio, Faulkner Georgine (May. 2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. (England) 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. ISSN 0022-2836. PMID 15136035.
^ Raffetseder, Ute; Frye Björn, Rauen Thomas, Jürchott Karsten, Royer Hans-Dieter, Jansen Petra Lynen, Mertens Peter R (May. 2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. (United States) 278 (20): 18241–8. doi:10.1074/jbc.M212518200. ISSN 0021-9258. PMID 12604611.
^ Chernukhin, I V; Shamsuddin S, Robinson A F, Carne A F, Paul A, El-Kady A I, Lobanenkov V V, Klenova E M (Sep. 2000). "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". J. Biol. Chem. (UNITED STATES) 275 (38): 29915–21. doi:10.1074/jbc.M001538200. ISSN 0021-9258. PMID 10906122.
^ Okamoto, T; Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K (Dec. 2000). "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene (England) 19 (54): 6194–202. doi:10.1038/sj.onc.1204029. ISSN 0950-9232. PMID 11175333.

[edit] Further reading

Kolluri R, Torrey TA, Kinniburgh AJ (1992). "A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif.". Nucleic Acids Res. 20 (1): 111–6. doi:10.1093/nar/20.1.111. PMC 310333. PMID 1738588. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310333.
Kolluri R, Kinniburgh AJ (1991). "Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein.". Nucleic Acids Res. 19 (17): 4771. doi:10.1093/nar/19.17.4771. PMC 328725. PMID 1891370. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=328725.
Sakura H, Maekawa T, Imamoto F, et al. (1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.". Gene 73 (2): 499–507. doi:10.1016/0378-1119(88)90514-8. PMID 2977358.
Didier DK, Schiffenbauer J, Woulfe SL, et al. (1988). "Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7322–6. doi:10.1073/pnas.85.19.7322. PMC 282178. PMID 3174636. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=282178.
Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain.". Eur. J. Biochem. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID 7628487.
Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins.". Mol. Cell. Biol. 15 (9): 5092–9. PMC 230756. PMID 7651426. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230756.
Chen NN, Chang CF, Gallia GL, et al. (1995). "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element.". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1087–91. doi:10.1073/pnas.92.4.1087. PMC 42642. PMID 7862639. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42642.
Horwitz EM, Maloney KA, Ley TJ (1994). "A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes.". J. Biol. Chem. 269 (19): 14130–9. PMID 8188694.
Kashanchi F, Duvall JF, Dittmer J, et al. (1994). "Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression.". J. Virol. 68 (1): 561–5. PMC 236322. PMID 8254772. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=236322.
Makino Y, Ohga T, Toh S, et al. (1996). "Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter.". Nucleic Acids Res. 24 (10): 1873–8. doi:10.1093/nar/24.10.1873. PMC 145870. PMID 8657568. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145870.
Funke B, Zuleger B, Benavente R, et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins.". Nucleic Acids Res. 24 (19): 3821–8. doi:10.1093/nar/24.19.3821. PMC 146158. PMID 8871564. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146158.
Koike K, Uchiumi T, Ohga T, et al. (1998). "Nuclear translocation of the Y-box binding protein by ultraviolet irradiation.". FEBS Lett. 417 (3): 390–4. doi:10.1016/S0014-5793(97)01296-9. PMID 9409758.
Toh S, Nakamura T, Ohga T, et al. (1998). "Genomic organization of the human Y-box protein (YB-1) gene.". Gene 206 (1): 93–7. doi:10.1016/S0378-1119(97)00570-2. PMID 9461420.
Sawaya BE, Khalili K, Amini S (1998). "Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat.". J. Gen. Virol.. 79 ( Pt 2): 239–46. PMID 9472608.
Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH (1999). "A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription.". J. Biol. Chem. 273 (49): 32957–65. doi:10.1074/jbc.273.49.32957. PMID 9830047.
Ise T, Nagatani G, Imamura T, et al. (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen.". Cancer Res. 59 (2): 342–6. PMID 9927044.
Safak M, Gallia GL, Khalili K (1999). "Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells.". Mol. Cell. Biol. 19 (4): 2712–23. PMC 84064. PMID 10082537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84064.
Kelm RJ, Cogan JG, Elder PK, et al. (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter.". J. Biol. Chem. 274 (20): 14238–45. doi:10.1074/jbc.274.20.14238. PMID 10318844.
Safak M, Gallia GL, Ansari SA, Khalili K (1999). "Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen.". J. Virol. 73 (12): 10146–57. PMC 113067. PMID 10559330. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=113067.
Ansari SA, Safak M, Gallia GL, et al. (1999). "Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity.". J. Gen. Virol.. 80 ( Pt 10): 2629–38. PMID 10573156.
Basaki Y, Hosoi F, Oda Y, et al. (2007). "Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells.". Oncogene 26 (19): 2736–46. doi:10.1038/sj.onc.1210084. PMID 17072343.

[edit] External links

MeSH YBX1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[0] "Entrez Gene: YBX1 Y box binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4904.

[pmid18851979-1] Chibi, Moredreck; Meyer Mervin, Skepu Amanda, G Rees D Jasper, Moolman-Smook Johanna C, Pugh David J R (Dec. 2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. (England) 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979.

[pmid9927044-2] Ise, T; Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (Jan. 1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. (UNITED STATES) 59 (2): 342–6. ISSN 0008-5472. PMID 9927044.

[pmid15136035-3] Kojic, Snezana; Medeot Elisa, Guccione Ernesto, Krmac Helena, Zara Ivano, Martinelli Valentina, Valle Giorgio, Faulkner Georgine (May. 2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. (England) 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. ISSN 0022-2836. PMID 15136035.

[pmid12604611-4] Raffetseder, Ute; Frye Björn, Rauen Thomas, Jürchott Karsten, Royer Hans-Dieter, Jansen Petra Lynen, Mertens Peter R (May. 2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. (United States) 278 (20): 18241–8. doi:10.1074/jbc.M212518200. ISSN 0021-9258. PMID 12604611.

[pmid10906122-5] Chernukhin, I V; Shamsuddin S, Robinson A F, Carne A F, Paul A, El-Kady A I, Lobanenkov V V, Klenova E M (Sep. 2000). "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". J. Biol. Chem. (UNITED STATES) 275 (38): 29915–21. doi:10.1074/jbc.M001538200. ISSN 0021-9258. PMID 10906122.

[pmid11175333-6] Okamoto, T; Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K (Dec. 2000). "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene (England) 19 (54): 6194–202. doi:10.1038/sj.onc.1204029. ISSN 0950-9232. PMID 11175333.

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Y box binding protein 1

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