CDX1

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Caudal type homeobox 1
Identifiers
Symbols CDX1 ; MGC116915
External IDs OMIM600746 MGI88360 HomoloGene1366 GeneCards: CDX1 Gene
RNA expression pattern
PBB GE CDX1 206430 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1044 12590
Ensembl ENSG00000113722 ENSMUSG00000024619
UniProt P47902 P18111
RefSeq (mRNA) NM_001804 NM_009880
RefSeq (protein) NP_001795 NP_034010
Location (UCSC) Chr 5:
149.55 – 149.56 Mb
Chr 18:
61.02 – 61.04 Mb
PubMed search [1] [2]

Homeobox protein CDX-1 is a protein that in humans is encoded by the CDX1 gene.[1][2]

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.[2]

References[edit]

  1. ^ Bonner CA, Loftus SK, Wasmuth JJ (Feb 1996). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027. 
  2. ^ a b "Entrez Gene: CDX1 caudal type homeobox transcription factor 1". 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.