LBX1

Ladybird homeobox 1
Identifiers
Symbols	LBX1; HPX-6; HPX6; LBX1H; homeobox
External IDs	OMIM: 604255 MGI: 104867 HomoloGene: 4784 GeneCards: LBX1 Gene
Gene Ontology Molecular function • transcription regulatory region sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • heart looping • multicellular organismal development • nervous system development • muscle organ development • negative regulation of cell proliferation • anatomical structure morphogenesis • regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification • cell differentiation • negative regulation of neuron differentiation • neuron fate determination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10660	16814
Ensembl	ENSG00000138136	ENSMUSG00000025216
UniProt	P52954	P52955
RefSeq (mRNA)	NM_006562.4	NM_010691.5
RefSeq (protein)	NP_006553.2	NP_034821.2
Location (UCSC)	Chr 10: 102.99 – 102.99 Mb	Chr 19: 45.31 – 45.31 Mb
PubMed search	[1]	[2]

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• de Mollerat XJ, Gurrieri F, Morgan CT, et al. (2004). "A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24.". Hum. Mol. Genet. 12 (16): 1959–71. doi:10.1093/hmg/ddg212. PMID 12913067. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Kozmik Z, Holland LZ, Schubert M, et al. (2001). "Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm.". Genesis 29 (4): 172–9. doi:10.1002/gene.1021. PMID 11309850. 
• Moretti P, Simmons P, Thomas P, et al. (1994). "Identification of homeobox genes expressed in human haemopoietic progenitor cells.". Gene 144 (2): 213–9. doi:10.1016/0378-1119(94)90380-8. PMID 7518789.