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CCAAT/enhancer binding protein (C/EBP), delta
Symbols CEBPD ; C/EBP-delta; CELF; CRP3; NF-IL6-beta
External IDs OMIM116898 MGI103573 HomoloGene3808 GeneCards: CEBPD Gene
Species Human Mouse
Entrez 1052 12609
Ensembl ENSG00000221869 n/a
UniProt P49716 Q00322
RefSeq (mRNA) NM_005195 NM_007679
RefSeq (protein) NP_005186 NP_031705
Location (UCSC) Chr 8:
48.65 – 48.65 Mb
PubMed search [1] [2]

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[1][2]

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[3]


CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor. [4]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy. [5]


CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[6]

See also[edit]


  1. ^ Cao Z, Umek RM, McKnight SL (October 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554. 
  2. ^ Williams SC, Cantwell CA, Johnson PF (October 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998. 
  3. ^ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta". 
  4. ^ Gery s (2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–97. doi:10.1038/sj.onc.1208393. PMID 15674331. 
  5. ^ Duitman J (Jan 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Lab Invest. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561. 
  6. ^ Choy, Lisa; Derynck Rik (March 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". J. Biol. Chem. (United States) 278 (11): 9609–19. doi:10.1074/jbc.M212259200. ISSN 0021-9258. PMID 12524424. 

Further reading[edit]

  • Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120. 
  • Kinoshita S, Akira S, Kishimoto T (1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1473–6. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402. 
  • Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).". J. Immunol. 155 (9): 4330–8. PMID 7594592. 
  • Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p.". Cytogenet. Cell Genet. 70 (3–4): 188–91. doi:10.1159/000134030. PMID 7789168. 
  • Cleutjens CB, van Eekelen CC, van Dekken H et al. (1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics 16 (2): 520–3. doi:10.1006/geno.1993.1220. PMID 8314590. 
  • Chen PL, Riley DJ, Chen Y, Lee WH (1997). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes Dev. 10 (21): 2794–804. doi:10.1101/gad.10.21.2794. PMID 8946919. 
  • Xia C, Cheshire JK, Patel H, Woo P (1998). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". Int. J. Biochem. Cell Biol. 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146. 
  • Zhu Y, Saunders MA, Yeh H et al. (2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". J. Biol. Chem. 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938. 
  • Angeloni D, Lee JD, Johnson BE et al. (2002). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Mol. Cell. Probes 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. PMID 11851384. 
  • Gao H, Parkin S, Johnson PF, Schwartz RC (2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". J. Biol. Chem. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Dearth LR, DeWille J (2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". J. Biol. Chem. 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732. 
  • Milde-Langosch K, Löning T, Bamberger AM (2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Res. Treat. 79 (2): 175–85. doi:10.1023/A:1023929504884. PMID 12825852. 
  • Kovács KA, Steinmann M, Magistretti PJ et al. (2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". J. Biol. Chem. 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754. 
  • Chen YW, Hubal MJ, Hoffman EP et al. (2004). "Molecular responses of human muscle to eccentric exercise". J. Appl. Physiol. 95 (6): 2485–94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035. 
  • Li R, Strohmeyer R, Liang Z et al. (2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiol. Aging 25 (8): 991–9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823. 
  • Sivko GS, Sanford DC, Dearth LD et al. (2005). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". J. Cell. Biochem. 93 (4): 844–56. doi:10.1002/jcb.20224. PMID 15389878. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.