From Wikipedia, the free encyclopedia
Jump to: navigation, search
Hes-related family bHLH transcription factor with YRPW motif-like
Symbols HEYL ; HESR3; HEY3; HRT3; bHLHb33
External IDs OMIM609034 MGI1860511 HomoloGene8494 GeneCards: HEYL Gene
RNA expression pattern
PBB GE HEYL 220662 s at tn.png
More reference expression data
Species Human Mouse
Entrez 26508 56198
Ensembl ENSG00000163909 ENSMUSG00000032744
UniProt Q9NQ87 Q9DBX7
RefSeq (mRNA) NM_014571 NM_013905
RefSeq (protein) NP_055386 NP_038933
Location (UCSC) Chr 1:
40.09 – 40.11 Mb
Chr 4:
123.23 – 123.25 Mb
PubMed search [1] [2]

Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.[1][2][3]

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.[3]


  1. ^ Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech Dev 85 (1-2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. 
  2. ^ Steidl C, Leimeister C, Klamt B, Maier M, Nanda I, Dixon M, Clarke R, Schmid M, Gessler M (Aug 2000). "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family". Genomics 66 (2): 195–203. doi:10.1006/geno.2000.6200. PMID 10860664. 
  3. ^ a b "Entrez Gene: HEYL hairy/enhancer-of-split related with YRPW motif-like". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.