The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM]
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^Ornatsky, O I; McDermott J C (October 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. (UNITED STATES) 271 (40): 24927–33. doi:10.1074/jbc.271.40.24927. ISSN0021-9258. PMID8798771.Cite uses deprecated parameters (help)
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Suzuki E, Lowry J, Sonoda G, et al. (1996). "Structures and chromosome locations of the human MEF2A gene and a pseudogene MEF2AP". Cytogenet. Cell Genet.73 (3): 244–9. doi:10.1159/000134348. PMID8697817.
Ornatsky OI, McDermott JC (1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem.271 (40): 24927–33. doi:10.1074/jbc.271.40.24927. PMID8798771.
Lemercier C, Verdel A, Galloo B, et al. (2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity". J. Biol. Chem.275 (20): 15594–9. doi:10.1074/jbc.M908437199. PMID10748098.
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