NFYB

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Nuclear transcription factor Y, beta
Protein NFYB PDB 1n1j.png
PDB rendering based on 1n1j.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NFYB ; CBF-A; CBF-B; HAP3; NF-YB
External IDs OMIM189904 MGI97317 HomoloGene38149 GeneCards: NFYB Gene
RNA expression pattern
PBB GE NFYB 218127 at tn.png
PBB GE NFYB 218128 at tn.png
PBB GE NFYB 218129 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4801 18045
Ensembl ENSG00000120837 ENSMUSG00000020248
UniProt P25208 P63139
RefSeq (mRNA) NM_006166 NM_010914
RefSeq (protein) NP_006157 NP_035044
Location (UCSC) Chr 12:
104.51 – 104.53 Mb
Chr 10:
82.75 – 82.76 Mb
PubMed search [1] [2]

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.[1][2]

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.[3]

Interactions[edit]

NFYB has been shown to interact with CCAAT/enhancer binding protein zeta,[4] CNTN2,[5] TATA binding protein[6] and Myc.[7]

References[edit]

  1. ^ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067. 
  2. ^ Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081. 
  3. ^ "Entrez Gene: NFYB nuclear transcription factor Y, beta". 
  4. ^ Imbriano, C; Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. (United States) 276 (28): 26332–9. doi:10.1074/jbc.M101553200. ISSN 0021-9258. PMID 11306579. 
  5. ^ Pise-Masison, C A; Dittmer J, Clemens K E, Brady J N (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. (UNITED STATES) 17 (3): 1236–43. ISSN 0270-7306. PMC 231848. PMID 9032250. 
  6. ^ Bellorini, M; Lee D K, Dantonel J C, Zemzoumi K, Roeder R G, Tora L, Mantovani R (Jun 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. (ENGLAND) 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. ISSN 0305-1048. PMC 146709. PMID 9153318. 
  7. ^ Izumi, H; Molander C, Penn L Z, Ishisaki A, Kohno K, Funa K (Apr 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell. Sci. (England) 114 (Pt 8): 1533–44. ISSN 0021-9533. PMID 11282029. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.