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Period circadian clock 3
Symbols PER3 ; GIG13
External IDs OMIM603427 MGI1277134 HomoloGene7886 GeneCards: PER3 Gene
RNA expression pattern
PBB GE PER3 221045 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8863 18628
Ensembl ENSG00000049246 ENSMUSG00000028957
UniProt P56645 O70361
RefSeq (mRNA) NM_001289861 NM_001289877
RefSeq (protein) NP_001276790 NP_001276806
Location (UCSC) Chr 1:
7.84 – 7.91 Mb
Chr 4:
151 – 151.04 Mb
PubMed search [1] [2]

The PER3 gene encodes the period circadian protein homolog 3 protein in humans.[1]

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.[2]

See also[edit]


  1. ^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr, Reppert SM (Jan 1998). "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei". Neuron 19 (6): 1261–9. doi:10.1016/S0896-6273(00)80417-1. PMID 9427249. 
  2. ^ "Entrez Gene: PER3 period homolog 3 (Drosophila)". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.