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Period circadian clock 3
Symbols PER3 ; GIG13
External IDs OMIM603427 MGI1277134 HomoloGene7886 GeneCards: PER3 Gene
RNA expression pattern
PBB GE PER3 221045 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8863 18628
Ensembl ENSG00000049246 ENSMUSG00000028957
UniProt P56645 O70361
RefSeq (mRNA) NM_016831 NM_011067
RefSeq (protein) NP_058515 NP_035197
Location (UCSC) Chr 1:
7.84 – 7.91 Mb
Chr 4:
151 – 151.04 Mb
PubMed search [1] [2]

Period circadian protein homolog 3 is a protein that in humans is encoded by the PER3 gene.[1]

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.[2]


  1. ^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr, Reppert SM (Jan 1998). "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei". Neuron 19 (6): 1261–9. doi:10.1016/S0896-6273(00)80417-1. PMID 9427249. 
  2. ^ "Entrez Gene: PER3 period homolog 3 (Drosophila)". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.