TBX21

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T-box 21
Identifiers
Symbols TBX21 ; T-PET; T-bet; TBET; TBLYM
External IDs OMIM604895 MGI1888984 HomoloGene8353 GeneCards: TBX21 Gene
RNA expression pattern
PBB GE TBX21 220684 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 30009 57765
Ensembl ENSG00000073861 ENSMUSG00000001444
UniProt Q9UL17 Q9JKD8
RefSeq (mRNA) NM_013351 NM_019507
RefSeq (protein) NP_037483 NP_062380
Location (UCSC) Chr 17:
47.73 – 47.75 Mb
Chr 11:
97.1 – 97.12 Mb
PubMed search [1] [2]

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.[1]

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.[1]

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