FOXO4

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Forkhead box O4
Protein MLLT7 PDB 1e17.png
PDB rendering based on 1e17.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FOXO4 ; AFX; AFX1; MLLT7
External IDs OMIM300033 MGI1891915 HomoloGene4342 GeneCards: FOXO4 Gene
RNA expression pattern
PBB GE MLLT7 205451 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4303 54601
Ensembl ENSG00000184481 ENSMUSG00000042903
UniProt P98177 Q9WVH3
RefSeq (mRNA) NM_001170931 NM_018789
RefSeq (protein) NP_001164402 NP_061259
Location (UCSC) Chr X:
70.32 – 70.32 Mb
Chr X:
101.25 – 101.26 Mb
PubMed search [1] [2]

Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene.[1][2]


See also[edit]

Interactions[edit]

FOXO4 has been shown to interact with PIN1[3] and Mdm2.[4]

References[edit]

  1. ^ Parry P, Wei Y, Evans G (Feb 1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer 11 (2): 79–84. doi:10.1002/gcc.2870110203. PMID 7529552. 
  2. ^ "Entrez Gene: MLLT7 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7". 
  3. ^ Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, van der Groep Petra, van Diest Paul J, van der Horst Armando, Smits Alida M M, Burgering Boudewijn M T (Sep 2008). "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors". Cancer Res. (United States) 68 (18): 7597–605. doi:10.1158/0008-5472.CAN-08-1059. PMID 18794148. 
  4. ^ Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, Jochemsen A G, Burgering Boudewijn M Th (2008). "Mdm2 Induces Mono-Ubiquitination of FOXO4". In Cookson, Mark R. PLoS ONE (United States) 3 (7): e2819. doi:10.1371/journal.pone.0002819. PMC 2475507. PMID 18665269. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.