From Wikipedia, the free encyclopedia
Jump to: navigation, search
Forkhead box O4
Protein MLLT7 PDB 1e17.png
PDB rendering based on 1e17.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FOXO4 ; AFX; AFX1; MLLT7
External IDs OMIM300033 MGI1891915 HomoloGene4342 GeneCards: FOXO4 Gene
RNA expression pattern
PBB GE MLLT7 205451 at tn.png
More reference expression data
Species Human Mouse
Entrez 4303 54601
Ensembl ENSG00000184481 ENSMUSG00000042903
UniProt P98177 Q9WVH3
RefSeq (mRNA) NM_001170931 NM_018789
RefSeq (protein) NP_001164402 NP_061259
Location (UCSC) Chr X:
70.32 – 70.32 Mb
Chr X:
101.25 – 101.26 Mb
PubMed search [1] [2]

Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene.[1][2]


FOXO4 has been shown to interact with PIN1[3] and Mdm2.[4]

See also[edit]


  1. ^ Parry P, Wei Y, Evans G (Feb 1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer 11 (2): 79–84. doi:10.1002/gcc.2870110203. PMID 7529552.  Check date values in: |year= / |date= mismatch (help)
  2. ^ "Entrez Gene: MLLT7 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7". 
  3. ^ Brenkman AB, de Keizer PL, van den Broek NJ, van der Groep P, van Diest PJ, van der Horst A et al. (Sep 2008). "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors". Cancer Res. 68 (18): 7597–605. doi:10.1158/0008-5472.CAN-08-1059. PMID 18794148. 
  4. ^ Brenkman AB, de Keizer PL, van den Broek NJ, Jochemsen AG, Burgering BM (2008). Cookson MR, ed. "Mdm2 induces mono-ubiquitination of FOXO4". PLoS ONE 3 (7): e2819. doi:10.1371/journal.pone.0002819. PMC 2475507. PMID 18665269. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.