JUNB

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Jun B proto-oncogene
Identifiers
Symbols JUNB ; AP-1
External IDs OMIM165161 MGI96647 HomoloGene7390 GeneCards: JUNB Gene
RNA expression pattern
PBB GE JUNB 201473 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3726 16477
Ensembl ENSG00000171223 ENSMUSG00000052837
UniProt P17275 P09450
RefSeq (mRNA) NM_002229 NM_008416
RefSeq (protein) NP_002220 NP_032442
Location (UCSC) Chr 19:
12.9 – 12.9 Mb
Chr 8:
84.98 – 84.98 Mb
PubMed search [1] [2]

Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene.[1][2] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Interactions[edit]

JUNB has been shown to interact with

See also[edit]

References[edit]

  1. ^ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell 59 (6): 987–997. doi:10.1016/0092-8674(89)90755-1. PMID 2513129. 
  2. ^ "Entrez Gene: JUNB jun B proto-oncogene". 
  3. ^ Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. 16 (12): 1509–17. doi:10.1101/gad.995502. PMC 186344. PMID 12080089. 
  4. ^ Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.